Cabozantinib: Administered as specified in the parent study.
Zanzalintinib: Administered as specified in the parent study.
Atezolizumab: Administered as specified in the parent study.
Nivolumab: Administered as specified in the parent study.
Abiraterone: Administered as specified in the parent study.
Prednisone: Administered as specified in the parent study.
Enzalutamide: Administered as specified in the parent study.
Study summary
The primary objective of this long-term extension study is to allow continued access to study treatment for eligible participants who are deriving clinical benefit in an Exelixis-sponsored study who do not have access to treatment locally.
Eligibility
Sex
ALL
Min age
—
Max age
—
Healthy volunteers
No
Key Inclusion Criteria:
* Eligible to continue receiving the study treatment in the parent study (that is, has not met parent study discontinuation/withdrawal criteria).
* Continuing to derive clinical benefit from the study treatment at the time of transition from the parent study as assessed by the investigator.
* Able to comply with the long-term extension study protocol as determined by the investigator.
* Able to receive the first dose of study treatment in this extension study within the specified treatment interruption window allowed by the parent study.
Key Exclusion Criteria:
* Meet any of the study treatment discontinuation criteria specified in the parent study at the time of enrollment in this extension study.
* Study treatment is commercially marketed in the participant's country for the participant-specific disease and is accessible to the participant.
* Treatment with any anticancer treatment (other than treatment permitted in the parent study) during the time between last treatment in the parent study and the first dose of study treatment in this long-term extension study.
* Permanent discontinuation of all study treatment(s) for any reason during the parent study or during the time between last treatment in the parent study and the first dose of study treatment in this long-term extension study (if applicable).
* Concurrent participation in any therapeutic clinical trial (other than the parent study).
NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.
Primary outcome measure(s)
Number of Participants With Treatment Emergent Adverse Events (TEAEs) — Up to 4 years (until the event resolves, returns to baseline, stabilizes, a new anticancer therapy is initiated, or the participant is lost to follow-up or withdraws consent, whichever occurs first)
Trial sites (2)
Facility
City
Region
Status
New York Cancer and Blood Specialists
Bay Shore
New York
Greater Dayton Cancer Center
Kettering
Ohio
Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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