Embryo Assessment Utilizing Timelapse Imaging in Conjunction With Preimplantation Genetic Testing for Aneuploidy With Next Generation Sequencing

Condition(s) studied

Investigational drug(s) / intervention(s)

Timelapse incubation and PGT: Patients will have their embryos cultured in a timelapse incubator and their PGT results will be compared to the data collected during timelapse incubation.

Study summary

The goal of this observational study is to discern if there is a relationship between timelapse imagery of human oocytes/embryos and PGT results.

Embryos of patients that are undergoing PGT will be placed into a timelapse incubator. The data obtained by the timelapse incubator will be used in conjunction with the PGT data to determine any relationships.

Eligibility

Primary outcome measure(s)

• Time to first cleavage — 24 hours
  time of embryo to undergo first cleavage
• Time to blastulation — 5-7 days
  time of embryo to form a blastocoel
• Fertilization morphology — 24 hours
  the morphological appearance of the pronuclei
• Embryo morphology — 2-7 days
  the morphological appearance of the embryos
• Patient age — 0 days
  Patient age
• Partner age — 0 days
  Partner age
• Partner diagnosis — 0 days
  Partner diagnosis
• Metabolomics of culture media — 7 days
  measurement of the spent culture media for amino acids, enzymes, and metabolites
• AMH — 0 days
  antimullerian hormone level in female's blood
• Days of stimulation — 0-15 days
  the number of days the patient underwent stimulation for IVF
• Dosage of stimulation meds — 0-15 days
  the amount of stimulation meds the patient took during IVF treatment
• Pregnancy — 2 weeks after transfer
  initial bhCG levels
• Patient diagnosis — 0 days
  Number of patients with each specific diagnosis, including low ovarian reserve, PCOS, primary infertility, secondary infertility, endometrosis, and unknown infertility.
• implantation — 4 weeks post transfer
  Number of patients that develope a sac within the uterus post transfer
• fetal cardiac heartbeat — 6 weeks
  Number of patients that develop a fetal cardiac heartbeat after transfer
• livebirth — approximately 9 months after transfer
  Number of patients that have a livebirth of an infant after IVF

Trial sites (1)

Other trials for the same condition