Dupilumab: Administered as described in the protocol
This study is researching an experimental drug called dupilumab. The study is focused on participants with active eosinophilic gastritis (EoG) with or without eosinophilic duodenitis (EoD). Participants with EoD only are not eligible for enrollment. EoG and EoD are uncommon, persistent, allergic/immune diseases in which eosinophils (a type of white blood cell) gather in large numbers in the stomach and small intestine and cause inflammation and damage.
The aim of the study is to evaluate the effect of dupilumab on relieving EoG (with or without EoD) symptoms and reducing inflammation in the stomach and, if applicable, small intestine in adults and adolescents aged 12 years and older after at least 24 weeks (about 6 months) and up to 52 weeks (1 year) of treatment.
The study is looking at several other research questions, including:
* What side effects may happen from taking the study drug
* How much study drug is in the blood at different times
* Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)
| Facility | City | Region | Status |
|---|---|---|---|
| Phoenix Childrens Hospital | Phoenix | Arizona | |
| Om Research LLC | Apple Valley | California | |
| Scripps Clinic | La Jolla | California | |
| Om Research LLC | Lancaster | California | |
| University of California - Los Angeles (UCLA) | Los Angeles | California | |
| University of Southern California Keck School of Medicine | Los Angeles | California | |
| GastroIntestinal BioSciences | Los Angeles | California | |
| United Medical Doctors | Murrieta | California | |
| Ucsf Medical Center (Benioff Childrens Hospital) | San Francisco | California | |
| University of Colorado Anschutz Health Science Building (AHSB) CU Research Pharmacy | Aurora | Colorado | |
| Connecticut Clinical Research Institute | Bristol | Connecticut | |
| UConn Health | Farmington | Connecticut | |
| Encore Borland-Groover Clinical Research | Jacksonville | Florida | |
| Northwestern University | Chicago | Illinois | |
| University Of Kansas | Kansas City | Kansas | |
| Beth Israel Deaconess Medical Center (BIDMC) Harvard Medical School | Boston | Massachusetts | |
| University of Michigan | Ann Arbor | Michigan | |
| MNGI Digestive Health P.A. | Plymouth | Minnesota | |
| Mayo Clinic Hospital Rochester | Rochester | Minnesota | |
| Advanced Research Institute | Reno | Nevada | |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | |
| Northwell Health | Great Neck | New York | |
| Icahn School of Medicine at Mount Sinai (ISMMS) - The Mount Sinai Hospital (MSH) | New York | New York | |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | |
| Charlotte Gastroenterology & Hepatology, PLLC | Charlotte | North Carolina | |
| Duke University | Durham | North Carolina | |
| ESI Medical Research, PLLC | Kinston | North Carolina | |
| University of Cincinnati Medical Center-Children's Hospital Medical Center | Cincinnati | Ohio | |
| Ohio State University Medical Center | Columbus | Ohio | |
| Allergy, Asthma and Clinical Research Center | Oklahoma City | Oklahoma | |
| The Oregon Clinic - Gastroenterology East | Portland | Oregon | |
| University of Pennsylvania | Philadelphia | Pennsylvania | |
| TDDC dba GI Alliance Research | Mansfield | Texas | |
| University of Utah | Salt Lake City | Utah | |
| Seattle Children's Home Health Company | Seattle | Washington | |
| Froedtert Hospital | Milwaukee | Wisconsin | |
| Stollery Children's Hospital - University of Alberta | Edmonton | Alberta | |
| Humanitas Research Hospital | Rozzano | Milan | |
| AOOR Villa Sofia/Cervello | Palermo | Sicily | |
| U.O. Di Ematologia-Azienda Policlinico Consorziale, Ospedaliero-Universitaria, Ospedale | Bari | Italy |
+ 13 more sites — see the full list on the official registry below.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT05831176 on ClinicalTrials.gov ↗ ← All trials in the USA