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Clinical Trials in the USA / NCT04155749
Active, not recruiting Phase 1

Study of Anitocabtagene-autoleucel in Participants With Relapsed Refractory Multiple Myeloma

NCT04155749 · tracked via the Priya Life Science USA tracker
Sponsor
Kite, A Gilead Company
Phase
Phase 1
Started
2019-12-23
Last updated
2026-02-11

Condition(s) studied

Relapsed and Refractory Multiple Myeloma

Investigational drug(s) / intervention(s)

anitocabtagene-autoleucel

anitocabtagene-autoleucel: Chimeric Antigen Receptor T cells

Study summary

Master protocol for cell therapy, Phase 1 proof-of-concept studies in relapsed and refractory multiple myeloma and includes long-term safety follow-up.

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria: * Relapsed and refractory Multiple Myeloma treated with at least 3 prior regimens of system therapy including Proteosome Inhibitor (PI), immunomodulatory drugs (IMiD), and anti-CD38 antibody (CD38mab); or has "triple-refractory" disease * Documented measurable disease * Adequate organ function * Life expectancy \> 12 weeks, Eastern Cooperative Group Performance Status 0-1 Exclusion Criteria: * Plasma Cell Leukemia or History of Plasma Cell Leukemia * Patients with a history of severe hypersensitivity to DMSO should be excluded * Contraindication to fludarabine or cyclophosphamide * Severe uncontrolled intercurrent illness (e.g., infection) or laboratory abnormalities * Active central nervous system disease involvement by malignancy or active CNS pathology

Primary outcome measure(s)

Trial sites (4)

FacilityCityRegionStatus
Advanced Cellular Therapeutics Facility, DCAM 0800A Chicago Illinois
Massachusetts General Hospital Boston Massachusetts
Beth Israel Deaconess Medical Center Boston Massachusetts
Froedtert Hospital/Medical College of Wisconsin Milwaukee Wisconsin

More Kite, A Gilead Company trials in the USA

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04155749 on ClinicalTrials.gov ↗ ← All trials in the USA