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Clinical Trials in the USA / NCT06079164
Active, not recruiting Phase 1

Study of KITE-197 in Participants With Relapsed or Refractory Large B-cell Lymphoma

NCT06079164 · tracked via the Priya Life Science USA tracker
Sponsor
Kite, A Gilead Company
Phase
Phase 1
Started
2023-11-09
Last updated
2026-08-25

Condition(s) studied

Relapsed/Refractory Large B-cell Lymphoma

Investigational drug(s) / intervention(s)

KITE-197CyclophosphamideFludarabine

KITE-197: A single infusion of CAR-transduced autologous T cells administered intravenously

Cyclophosphamide: Lymphodepleting chemotherapy administered intravenously

Fludarabine: Lymphodepleting chemotherapy administered intravenously

Study summary

This study will have two Phases: Phase 1a and Phase 1b. The goal of Phase 1a of this clinical study is to learn more about the safety, tolerability and dosing of study drug KITE-197, in participants with relapsed or refractory large B-cell lymphoma (r/rLBCL). The goal of Phase 1b of this clinical study is learn about the effectiveness of the recommended dose of KITE-197 in participants with r/r LBCL.

The primary objectives of this study are:

Phase 1a: To evaluate the safety of KITE-197 in participants with r/r LBCL and determine the target dose level for Phase 1b.

Phase 1b: To evaluate the efficacy of KITE-197 in participants with r/r LBCL as measured by the complete remission (CR) rate.

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Key Inclusion Criteria: * Relapsed or Refractory Large B-cell Lymphoma * At least 1 measurable lesion * Adequate organ and bone marrow function Key Exclusion Criteria: * History of malignancy other than nonmelanoma skin cancer or carcinoma in situ (eg, cervix, bladder, breast) unless disease free for at least 2 years * History of Richter's transformation of chronic leukemic lymphoma * History of allogenic stem cell transplant (SCT) * Autologous SCT within 6 weeks of planned KITE-197 infusion * Prior CD19 targeted antibody, such as tafasitamab and loncastuximab with the exception of individuals who have previously achieved an objective response to such therapy and their tumor expresses CD19 by International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (IHC) at the time of screening. Individuals who meet these criteria may be eligible * Prior treatment with bendamustine within 6 months of enrollment * Prior CAR therapy or other genetically modified cell therapy * Presence or suspicion of fungal, bacterial, viral, or other infection that is uncontrolled or requiring IV antimicrobials for management * History of HIV infection or acute or chronic active hepatitis B or C infection * History or presence of a clinically significant central nervous system (CNS) disorder Note: Prior or active CNS involvement by lymphoma is not an exclusion criterion. * History of myocardial infarction, cardiac angioplasty or stenting, unstable angina, New York Heart Association Class II or greater congestive heart failure, or other clinically significant cardiac disease within 12 months before enrollment * Presence of primary immunodeficiency * History of autoimmune disease (eg, Crohn's disease, rheumatoid arthritis, systemic lupus) resulting in end organ injury or requiring systemic immunosuppression/systemic disease modifying agents within the last 2 years * History of symptomatic deep vein thrombosis (DVT) or pulmonary embolism within 3 months before enrollment. Catheter induced DVT which has been treated for at least 6 weeks prior to enrollment is permitted * Females of childbearing potential who are pregnant or breastfeeding because of the potentially dangerous effects of the preparative chemotherapy on the fetus or infant Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Primary outcome measure(s)

Trial sites (11)

FacilityCityRegionStatus
Sylvester Comprehensive Cancer Center Miami Florida
University of Chicago Medical Center Chicago Illinois
Henry-Joyce Cancer Clinic Nashville Tennessee
St. David's South Austin Medical Center Austin Texas
Swedish Cancer Institute Seattle Washington
Royal Prince Alfred Hospital Camperdown New South Wales
Royal Brisbane and Women's Hospital South Brisbane Queensland
The Alfred Hospital Melbourne Victoria
Cross Cancer Institute Edmonton Canada
QEII Health Sciences Centre Halifax Canada
Jewish General Hospital Montreal Canada

More Kite, A Gilead Company trials in the USA

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06079164 on ClinicalTrials.gov ↗ ← All trials in the USA