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Trackers› Clinical trials› Pulmonary Arterial Hypertension
Clinical trial register · United States · industry-sponsored

Pulmonary Arterial Hypertension Trials in the USA

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors — the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

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Source: ClinicalTrials.gov. Complete coverage of the industry-sponsored slice — all 9094 matching records are in this view (non-industry sponsors are out of scope by design, not truncated). Synced 17 Sep 2026, 08:23 UTC
9094
Studies in scope
industry-sponsored, all four open statuses
4935
Recruiting now
open to new participants
2188
Lead sponsors
across recruiting studies
Top states
California 14 Florida 11 Colorado 8 Illinois 7 New York 6
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
Merck Sharp & Dohme LLC3 United Therapeutics3 Actelion2 Insmed Incorporated2 Gossamer Bio USA, Inc.2
State
California14 Florida11 Colorado8 Illinois7 New York6
All 30 states
Target enrolment
to
18 of 9094 studies
Download
Status
Study
Lead sponsor
Phase
Enrol
US states
Start
Recruiting
A Study of HS235 for Treatment of Pulmonary Arterial Hypertension (PAH) in Adults
NCT07143448Pulmonary Arterial Hypertension
35Pharma Inc
Phase 1/2
90
Florida, Rhode Island
2026-08-19
Recruiting
A Study to Evaluate the Efficacy and Safety of Once Daily Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Arterial Hypertension (PAH)
NCT07481981Pulmonary Arterial Hypertension
Insmed Incorporated
Phase 3
344
California, Kansas, Nebraska, New York, Pennsylvania, South Carolina
2026-07-21
Recruiting
An Adaptive Program of IKT-001 in Pulmonary Arterial Hypertension (PAH)
NCT07365332Pulmonary Arterial Hypertension
Inhibikase Therapeutics
Phase 3
486
Arizona, California, Colorado, Kansas, Kentucky, Massachusetts, Missouri, New York
2026-04-23
Active, closed
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-031/LIGHTRAY EXTENSION)
NCT06925750Pulmonary Arterial Hypertension
Merck Sharp & Dohme LLC
Phase 2
130
Colorado, Kansas, New Mexico
2025-05-12
Recruiting
Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)
NCT06274801Pulmonary Arterial Hypertension
Gossamer Bio USA, Inc.
Phase 3
330
California, Florida, Georgia, Illinois, Kansas, Kentucky, Michigan, Missouri
2024-09-03
Active, closed
An Extension Study of Treprostinil Palmitil Inhalation Powder (TPIP) for Pulmonary Arterial Hypertension (PAH)
NCT05649748Pulmonary Arterial Hypertension
Insmed Incorporated
Phase 2/3
91
Florida, Illinois, New York, Texas
2023-03-07
Recruiting
Study to Evaluate Sotatercept (MK-7962) in Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-008)
NCT05587712Pulmonary Arterial Hypertension
Merck Sharp & Dohme LLC
Phase 2
42
California, Colorado, District of Columbia, Ohio, Pennsylvania, Tennessee, Washington, Wisconsin
2023-01-19
Active, closed
A Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Participants With Pulmonary Arterial Hypertension
NCT05203510Pulmonary Arterial Hypertension
United Therapeutics
Phase 4
52
Arizona, California, Connecticut, Florida, Georgia, Illinois, Indiana, Massachusetts
2022-10-20
Active, closed
A Phase 3 Study to Evaluate the Safety and Tolerability of L606 in Subjects With PAH or PH-ILD
NCT04691154Pulmonary Arterial Hypertension, Pulmonary Hypertension Due to Lung Diseases
Liquidia Technologies, Inc.
Phase 3
28
Arizona, California, Florida, New York, Ohio, Oregon, Texas
2021-08-01
Recruiting
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
NCT07218029Pulmonary Arterial Hypertension
Merck Sharp & Dohme LLC
Phase 3
815
Arizona, California, Colorado, District of Columbia, Florida, Kansas, Kentucky, Maryland
2021-05-12
Active, closed
Open-label Extension Study of GB002 in Adult Subjects With Pulmonary Arterial Hypertension (PAH)
NCT04816604Pulmonary Arterial Hypertension
Gossamer Bio USA, Inc.
Phase 2
74
California, Florida, Kansas, Kentucky, Massachusetts, Nebraska, New York, Ohio
2021-04-05
Recruiting
Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System
NCT04555161Pulmonary Arterial Hypertension, Pulmonary Hypertension, Right Heart Dysfunction
Aria CV, Inc
Not applicable
30
California, Indiana, Massachusetts, Minnesota, New York, Ohio, South Carolina, Wisconsin
2021-03-15
Active, closed
Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension
NCT04273945Pulmonary Arterial Hypertension
Actelion
Phase 3
935
Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana, Iowa
2020-06-30
Active, closed
Reducing Right Ventricular Failure in Pulmonary Arterial Hypertension (RELIEVE-PAH)
NCT03838445Pulmonary Arterial Hypertension
V-Wave Ltd
Not applicable
9
California
2020-02-14
By invitation
A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension
NCT03683186PAH, Pulmonary Hypertension, Pulmonary Arterial Hypertension, Hypertension
United Therapeutics
Phase 3
1,000
Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana, Iowa
2019-09-23
Active, closed
A Clinical Study of to Confirm the Doses of Selexipag in Children With Pulmonary Arterial Hypertension
NCT03492177Pulmonary Arterial Hypertension
Actelion
Phase 2
63
Colorado, Iowa, Washington
2018-07-23
Active, closed
ADAPT - A Patient Registry of the Real-world Use of Orenitram®
NCT03045029Pulmonary Arterial Hypertension
United Therapeutics
Observational
300
California, Colorado, Florida, Georgia, Illinois, Indiana, Iowa, Kentucky
2017-07-18
Active, closed
DelIVery for Pulmonary Arterial Hypertension (PAH) & Continued Support Study
NCT01321073Pulmonary Arterial Hypertension
Medtronic Cardiac Rhythm and Heart Failure
Not applicable
64
Alabama, California, Florida, Illinois, Massachusetts, Minnesota, Texas, Wisconsin
2011-06
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Cite this view

Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 17 September 2026. https://priyalifescience.com/clinical-trials-usa/condition/pulmonary-arterial-hypertension

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Listing here is informational and not medical advice; eligibility is determined by each study team. Compare pay for the teams running these studies in the US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish, UK and EU sites, see the Ireland, UK and EU registers.