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Trackers› Clinical trials› Mitral Regurgitation
Clinical trial register · United States · industry-sponsored

Mitral Regurgitation Trials in the USA

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors — the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

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Source: ClinicalTrials.gov. Complete coverage of the industry-sponsored slice — all 9094 matching records are in this view (non-industry sponsors are out of scope by design, not truncated). Synced 17 Sep 2026, 08:23 UTC
9094
Studies in scope
industry-sponsored, all four open statuses
4935
Recruiting now
open to new participants
2188
Lead sponsors
across recruiting studies
Top states
California 13 Georgia 10 Illinois 7 Minnesota 7 Arizona 7
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
Abbott Medical Devices5 Edwards Lifesciences4 CardioMech AS1 4C Medical Technologies, Inc.1 Polares Medical SA1
State
California13 Georgia10 Illinois7 Minnesota7 Arizona7
All 28 states
Target enrolment
to
15 of 9094 studies
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Status
Study
Lead sponsor
Phase
Enrol
US states
Start
Recruiting
EFS of Posterior Leaflet Replacement to Reduce Mitral Regurgitation (United States)
NCT07517588Mitral Regurgitation
Polares Medical SA
Not applicable
15
Georgia, New York, Ohio
2026-09-01
Recruiting
Reduction or Elimination of Mitral Regurgitation With the SATURN TMVR System (CASSINI-US)
NCT07130994Mitral Regurgitation, Heart Disease
InnovHeart
Not applicable
15
California, New York, Oregon
2026-08-05
Recruiting
A Clinical Study of GeminiOne TEER System for the Treatment of Severe, Symptomatic MR.
NCT07086534Mitral Regurgitation
Sierra Valve LLC
Not applicable
15
California
2026-03-26
Recruiting
Abbott Cephea Mitral Valve Disease Registry
NCT07069673Mitral Regurgitation, Mitral Stenosis, Mitral Valve Disease, Mitral Valve (MV) Regurgitation
Abbott Medical Devices
Observational
1,000
Alabama, Arizona, California, Georgia, Illinois, Indiana, Kansas, Minnesota
2025-08-13
Recruiting
ATLAS (AltaValve) Pivotal Trial
NCT06465745Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation
4C Medical Technologies, Inc.
Not applicable
450
Arizona, California, Florida, Georgia, Louisiana, Maryland, Massachusetts, Michigan
2024-09-03
Recruiting
Cephea Early Feasibility Study
NCT05061004Mitral Regurgitation
Abbott Medical Devices
Not applicable
90
Arizona, California, Georgia, Illinois, Kansas, Michigan, Minnesota, New York
2022-04-28
Recruiting
EFS of the CardioMech MVRS
NCT04820764Mitral Regurgitation
CardioMech AS
Not applicable
25
California, Illinois, Kansas, Minnesota, New York, North Carolina, Ohio, Tennessee
2021-07-27
Recruiting
Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study
NCT04761120Mitral Regurgitation, Tricuspid Regurgitation, Valvular Heart Disease
Abbott Medical Devices
Observational
550
North Carolina, Wisconsin
2021-02-01
Active, closed
Beating Heart Mitral Valve Repair With the HARPOON™ System
NCT04375332Mitral Regurgitation
Edwards Lifesciences
Not applicable
25
California, Georgia, Maryland, Michigan, Minnesota, Oregon, Tennessee, Utah
2020-12-16
Recruiting
The ENCIRCLE Trial
NCT04153292Mitral Regurgitation, Mitral Valve Insufficiency
Edwards Lifesciences
Not applicable
900
Alabama, Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana
2020-11-12
Recruiting
An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System
NCT04029337Mitral Regurgitation
HighLife SAS
Not applicable
30
Arizona, California, Georgia, Massachusetts, Minnesota, New York, Pennsylvania, South Carolina
2020-07-14
Active, closed
MitraClip EXPAND G4 Study
NCT04177394Mitral Valve Regurgitation, Mitral Regurgitation
Abbott Medical Devices
Observational
1,164
Alabama, Arkansas, California, Connecticut, Florida, Illinois, Kansas, Minnesota
2020-01-17
Active, closed
Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial
NCT03706833Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
Edwards Lifesciences
Not applicable
1,247
Arizona, California, Colorado, District of Columbia, Florida, Georgia, Illinois, Indiana
2018-11-30
Active, closed
Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation
NCT03433274Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases
Abbott Medical Devices
Not applicable
103
Alabama, Arizona, Arkansas, California, Colorado, Florida, Georgia, Idaho
2018-06-15
Active, closed
SAPIEN M3 EFS: Early Feasibility Study of the Edwards SAPIEN M3 System for the Treatment of Mitral Regurgitation
NCT03230747Mitral Regurgitation, Mitral Disease
Edwards Lifesciences
Not applicable
72
California, Georgia, Illinois, Michigan, Minnesota, Utah, Virginia
2017-09-14
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Cite this view

Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 17 September 2026. https://priyalifescience.com/clinical-trials-usa/condition/mitral-regurgitation

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Listing here is informational and not medical advice; eligibility is determined by each study team. Compare pay for the teams running these studies in the US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish, UK and EU sites, see the Ireland, UK and EU registers.