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Clinical Trials in the UK / NCT06605378
Recruiting Observational

Prevalence of Antibodies and Cytokines in Participants With Chronic Granulomatous Disease

NCT06605378 · tracked via the Priya Life Science UK tracker
Sponsor
Ensoma
Phase
Observational
Started
2024-11-18
Last updated
2026-08-17

Condition(s) studied

Chronic Granulomatous Disease (CGD)

Study summary

This research study is designed to assess the prevalence of specific antibodies and inflammatory cytokines in adult and pediatric participants with CGD.

Eligibility

Sex
ALL
Min age
Max age
Healthy volunteers
No
Inclusion Criteria: * The participant must have been diagnosed with CGD based on the referring physician's confirmation that NADPH oxidase activity is ≤5% (i.e., the percentage of dihydrorhodamine-positive \[DHR+\] cells is ≤5% by flow cytometry) OR based on confirmed pathogenic mutation in a CGD associated gene (CYBB, CYBA, NCF1, NCF2, NCF4, or CYBC1). * The participant or the participant's legally authorized guardian or representative (if applicable) must be capable of giving signed informed consent. * The participant (with assistance from the participant's legally authorized guardian/representative or primary caregiver, if applicable) must be capable of complying with the requirements and restrictions listed in the protocol and informed consent form (ICF). Exclusion Criteria: * The participant has undergone an allogeneic bone marrow transplant or investigational gene therapy. * The participant is unable to comply with the sample collection procedure based on investigator judgment.

Primary outcome measure(s)

Trial sites (52)

FacilityCityRegionStatus
Home-based telemedicine Montgomery Alabama Recruiting
Home-based telemedicine Phoenix Arizona Recruiting
Home-based telemedicine Little Rock Arkansas Recruiting
Home-based telemedicine Sacramento California Recruiting
University of California, San Francisco San Francisco California Recruiting
Home-based telemedicine Denver Colorado Recruiting
Home-based telemedicine Hartford Connecticut Recruiting
Home-based telemedicine Dover Delaware Recruiting
Home-based telemedicine Washington D.C. District of Columbia Recruiting
Home-based telemedicine Tallahassee Florida Recruiting
Home-based telemedicine Atlanta Georgia Recruiting
Home-based telemedicine Boise Idaho Recruiting
Home-based telemedicine Springfield Illinois Recruiting
Home-based telemedicine Indianapolis Indiana Recruiting
Home-based telemedicine Des Moines Iowa Recruiting
Home-based telemedicine Topeka Kansas Recruiting
Home-based telemedicine Frankfort Kentucky Recruiting
Home-based telemedicine Baton Rouge Louisiana Recruiting
Home-based telemedicine Augusta Maine Recruiting
Home-based telemedicine Annapolis Maryland Recruiting
Home-based telemedicine Boston Massachusetts Recruiting
Home-based telemedicine Lansing Michigan Recruiting
Home-based telemedicine Saint Paul Minnesota Recruiting
Home-based telemedicine Jackson Mississippi Recruiting
Home-based telemedicine Jefferson City Missouri Recruiting
Home-based telemedicine Helena Montana Recruiting
Home-based telemedicine Lincoln Nebraska Recruiting
Home-based telemedicine Carson City Nevada Recruiting
Home-based telemedicine Concord New Hampshire Recruiting
Home-based telemedicine Trenton New Jersey Recruiting
Home-based telemedicine Santa Fe New Mexico Recruiting
Home-based telemedicine Albany New York Recruiting
Science 37, Inc Morrisville North Carolina Recruiting
Home-based telemedicine Bismarck North Dakota Recruiting
Home-based telemedicine Columbus Ohio Recruiting
Home-based telemedicine Oklahoma City Oklahoma Recruiting
Home-based telemedicine Salem Oregon Recruiting
Home-based telemedicine Harrisburg Pennsylvania Recruiting
Home-based telemedicine Providence Rhode Island Recruiting
Home-based telemedicine Columbia South Carolina Recruiting

+ 12 more sites — see the full list on the official registry below.

More Ensoma trials in the UK

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06605378 on ClinicalTrials.gov ↗ ← All trials in the UK