Clinical Trials in the UK / NCT06605378
Recruiting
Observational
Prevalence of Antibodies and Cytokines in Participants With Chronic Granulomatous Disease
NCT06605378 · tracked via the Priya Life Science UK tracker
Condition(s) studied
Chronic Granulomatous Disease (CGD)
Study summary
This research study is designed to assess the prevalence of specific antibodies and inflammatory cytokines in adult and pediatric participants with CGD.
Eligibility
Inclusion Criteria:
* The participant must have been diagnosed with CGD based on the referring physician's confirmation that NADPH oxidase activity is ≤5% (i.e., the percentage of dihydrorhodamine-positive \[DHR+\] cells is ≤5% by flow cytometry) OR based on confirmed pathogenic mutation in a CGD associated gene (CYBB, CYBA, NCF1, NCF2, NCF4, or CYBC1).
* The participant or the participant's legally authorized guardian or representative (if applicable) must be capable of giving signed informed consent.
* The participant (with assistance from the participant's legally authorized guardian/representative or primary caregiver, if applicable) must be capable of complying with the requirements and restrictions listed in the protocol and informed consent form (ICF).
Exclusion Criteria:
* The participant has undergone an allogeneic bone marrow transplant or investigational gene therapy.
* The participant is unable to comply with the sample collection procedure based on investigator judgment.
Primary outcome measure(s)
- Total adenoviral-specific antibody (TAb) titer — 1 Day
Level of total adenoviral-specific antibody in blood - Adenoviral-specific neutralizing antibody (NAb) titer — 1 Day
Level of adenoviral-specific neutralizing antibodies in blood
Trial sites (52)
| Facility | City | Region | Status |
|---|---|---|---|
| Home-based telemedicine | Montgomery | Alabama | Recruiting |
| Home-based telemedicine | Phoenix | Arizona | Recruiting |
| Home-based telemedicine | Little Rock | Arkansas | Recruiting |
| Home-based telemedicine | Sacramento | California | Recruiting |
| University of California, San Francisco | San Francisco | California | Recruiting |
| Home-based telemedicine | Denver | Colorado | Recruiting |
| Home-based telemedicine | Hartford | Connecticut | Recruiting |
| Home-based telemedicine | Dover | Delaware | Recruiting |
| Home-based telemedicine | Washington D.C. | District of Columbia | Recruiting |
| Home-based telemedicine | Tallahassee | Florida | Recruiting |
| Home-based telemedicine | Atlanta | Georgia | Recruiting |
| Home-based telemedicine | Boise | Idaho | Recruiting |
| Home-based telemedicine | Springfield | Illinois | Recruiting |
| Home-based telemedicine | Indianapolis | Indiana | Recruiting |
| Home-based telemedicine | Des Moines | Iowa | Recruiting |
| Home-based telemedicine | Topeka | Kansas | Recruiting |
| Home-based telemedicine | Frankfort | Kentucky | Recruiting |
| Home-based telemedicine | Baton Rouge | Louisiana | Recruiting |
| Home-based telemedicine | Augusta | Maine | Recruiting |
| Home-based telemedicine | Annapolis | Maryland | Recruiting |
| Home-based telemedicine | Boston | Massachusetts | Recruiting |
| Home-based telemedicine | Lansing | Michigan | Recruiting |
| Home-based telemedicine | Saint Paul | Minnesota | Recruiting |
| Home-based telemedicine | Jackson | Mississippi | Recruiting |
| Home-based telemedicine | Jefferson City | Missouri | Recruiting |
| Home-based telemedicine | Helena | Montana | Recruiting |
| Home-based telemedicine | Lincoln | Nebraska | Recruiting |
| Home-based telemedicine | Carson City | Nevada | Recruiting |
| Home-based telemedicine | Concord | New Hampshire | Recruiting |
| Home-based telemedicine | Trenton | New Jersey | Recruiting |
| Home-based telemedicine | Santa Fe | New Mexico | Recruiting |
| Home-based telemedicine | Albany | New York | Recruiting |
| Science 37, Inc | Morrisville | North Carolina | Recruiting |
| Home-based telemedicine | Bismarck | North Dakota | Recruiting |
| Home-based telemedicine | Columbus | Ohio | Recruiting |
| Home-based telemedicine | Oklahoma City | Oklahoma | Recruiting |
| Home-based telemedicine | Salem | Oregon | Recruiting |
| Home-based telemedicine | Harrisburg | Pennsylvania | Recruiting |
| Home-based telemedicine | Providence | Rhode Island | Recruiting |
| Home-based telemedicine | Columbia | South Carolina | Recruiting |
+ 12 more sites — see the full list on the official registry below.
More Ensoma trials in the UK
Study of EN-374 Gene Therapy in Participants With X-Linked Chronic Granulomatous Disease
Active, not recruiting
Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06605378 on ClinicalTrials.gov ↗ ← All trials in the UK