🇮🇪Ireland
16°C Partly Cloudy · Dublin
Live Updates
--:--:-- IST
Writer Login
Latest
Clinical Trials in the UK / NCT06090539
Recruiting Phase 1/2

A Study to Assess BMS-986458 Alone and in Combination With Anti-lymphoma Agents in Relapsed/Refractory Non-Hodgkin Lymphomas

NCT06090539 · tracked via the Priya Life Science UK tracker
Sponsor
Bristol-Myers Squibb
Phase
Phase 1/2
Started
2023-12-29
Last updated
2026-09-14

Condition(s) studied

Relapsed/Refractory Non-Hodgkin Lymphoma

Investigational drug(s) / intervention(s)

BMS-986458RituximabGlofitamab/ObinutuzumabMosunetuzumabEpcoritamabGolcadomide

BMS-986458: Specified dose on specified days.

Rituximab: Specified dose on specified days.

Glofitamab/Obinutuzumab: Specified dose on specified days

Mosunetuzumab: Specified dose on specified days

Epcoritamab: Specified dose on specified days

Golcadomide: Specified dose on specified days

Study summary

The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary biological and clinical activity of BMS-986458, a bifunctional cereblon-dependent ligand-directed degrader of B-cell lymphoma 6 (BCL6), as a single agent and in combination with anti-lymphoma agents in participants with relapsed/refractory non-Hodgkin Lymphoma.

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria: * Participants ≥ 18 years of age with frontline or R/R NHL. * Participant must have measurable disease (defined by at least one FDG-avid lesion for FDG-avid disease and one bi-dimensionally measurable disease on cross sectional imaging by computed tomography or magnetic resonance imaging with at least one lesion \> 1.5 cm in the transverse diameter). * Participants must accept and follow pregnancy prevention plan. Exclusion Criteria: * Participants must not have an Eastern Cooperative Oncology Group (ECOG) performance status ≥ 2. * Participants with an inability to comply with listed restrictions, precautions and prohibited treatments. * Participants must not have prior CAR-T, or radiotherapy ≤ 4 weeks, systemic anticancer treatment ≤ 5 half-lives or 4 weeks, allogeneic SCT ≤ 6 months (only applicable to BMS-986458 single agent or rituximab combination cohorts), or autologous SCT ≤ 3 months prior to study intervention initiation. * In BMS-986458 + T-cell engager combination cohorts: Participants must not have prior alloSCT or solid organ transplantation, history of confirmed progressive multifocal leukoencephalopathy (PML); known or suspected history of hemophagocytic lymphohistiocytosis (HLH); known or suspected chronic active Epstein-Barr (EBV) infection. * Participants must not have any condition, including significant acute or chronic medical illness, active or uncontrolled infection, or the presence of laboratory abnormalities, that places participants at unacceptable risk if participating in this study. * Participants must not have known or suspected central nervous system involvement. * Other protocol-defined Inclusion/Exclusion criteria apply.

Primary outcome measure(s)

Trial sites (75)

FacilityCityRegionStatus
Mayo Clinic in Arizona - Phoenix Phoenix Arizona Recruiting
City of Hope Comprehensive Cancer Center Duarte California Recruiting
Local Institution - 0068 Jacksonville Florida Not Yet Recruiting
Moffitt Cancer Center Tampa Florida Recruiting
Dana-Farber Cancer Institute Boston Massachusetts Recruiting
Mayo Clinic in Rochester, Minnesota Rochester Minnesota Recruiting
Local Institution - 0124 Omaha Nebraska Not Yet Recruiting
Local Institution - 0047 Lake Success New York Completed
Local Institution - 0037 New York New York Not Yet Recruiting
Memorial Sloan Kettering Cancer Center New York New York Recruiting
Local Institution - 0045 Providence Rhode Island Not Yet Recruiting
Local Institution - 0118 Antofagasta AN Not Yet Recruiting
Local Institution - 0105 Santiago Metropolitana de Santiago Not Yet Recruiting
Local Institution - 0109 Santiago Santiago Metropolitan Not Yet Recruiting
Beijing Cancer hospital Beijing Beijing Municipality Recruiting
Local Institution - 0084 Guangzhou Guangdong Not Yet Recruiting
Local Institution - 0087 Zhengzhou Henan Not Yet Recruiting
Local Institution - 0120 Suzhou Jiangsu Not Yet Recruiting
The First Affiliated Hospital of Nanchang University Nanchang Jiangxi Recruiting
Local Institution - 0130 Nanchang Jiangxi Not Yet Recruiting
Local Institution - 0129 Shenyang Liaoning Not Yet Recruiting
Local Institution - 0131 Shanghai Shanghai Municipality Not Yet Recruiting
Local Institution - 0128 Hangzhou Zhejiang Not Yet Recruiting
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest Bordeaux Aquitaine Recruiting
Local Institution - 0125 Lyon Nan Not Yet Recruiting
Hopital Claude Huriez - CHU de Lille Lille Nord Recruiting
Gustave Roussy Villejuif Paris Recruiting
Henri Mondor Hospital Créteil Val-de-Marne Recruiting
CHU SAINT ELOI - Departement Hematologie Clinique Montpellier France Recruiting
Hôpital Saint-Louis Paris France Recruiting
Institut Claudius Regaud Toulouse France Recruiting
Universitätsklinikum Münster - Albert Schweitzer Campus Münster North Rhine-Westphalia Recruiting
Universitaetsklinikum des Saarlandes Homburg Saarland Recruiting
Universitätsklinikum Leipzig Leipzig Saxony Recruiting
Helios Klinikum Berlin-Buch Berlin Germany Recruiting
Universitaetsklinikum Essen Essen Germany Recruiting
Local Institution - 0103 Pátrai Achaḯa Not Yet Recruiting
Local Institution - 0107 Athens Greece Not Yet Recruiting
Local Institution - 0102 Athens Greece Not Yet Recruiting
Local Institution - 0119 Hong Kong Hong Kong Not Yet Recruiting

+ 35 more sites — see the full list on the official registry below.

On this site

📄 Rituxan (rituximab) drug profile →

More Bristol-Myers Squibb trials in the UK

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06090539 on ClinicalTrials.gov ↗ ← All trials in the UK