The purpose of this study is to assess the clinical effectiveness of all approved multiple myeloma (MM) therapies in the newly-diagnosed (NDMM) and the relapsed/refractory MM (RRMM) settings in real-world clinical practice.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
For more information regarding Bristol-Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com
Inclusion Criteria:
For RRMM participants who have received at least one prior line of therapy (LoT) for MM:
* Have documented progression from a prior LoT
* Participants who have initiated treatment with one of the following therapies within 90 days before consent for this study OR in the case where treatment has not yet been initiated, documentation that the treatment strategy was determined before consent for this study must be provided, and treatment must be initiated within 30 days after consent:
* IMiDs
* PIs
* Combination of IMiD + PI
* Newer agents with novel MOAs alone or in combination (eg, mAbs, HDACIs, Akt inhibitors, SINE, or CAR T-cell therapies)
For NDMM participants receiving frontline therapy:
* Eligible to receive frontline therapy for MM (no prior MM treatment)
* Participants who have initiated treatment for MM with one of the following therapies within 90 days before consent for this study OR in the case where treatment has not yet been initiated, documentation that the treatment strategy was determined before consent for this study must be provided, and treatment must be initiated within 30 days after consent:
* IMiDs
* PIs
* Combination of IMiD + PI
* Newer agents with novel MOAs alone or in combination (eg, mAbs, HDACIs, Akt inhibitors, SINE, or CAR T-cell therapies)
Exclusion Criteria:
* Participants who are currently participating in a clinical trial for MM
* Participants who are currently receiving treatment for primary cancer other than MM
* Participants who are not willing or able to provide informed consent
* Participants who are incarcerated
* Participants under compulsory detention for treatment of a physical (eg, infectious) or psychiatric illness
Other protocol-defined inclusion/exclusion criteria apply
Primary outcome measure(s)
Overall Survival (OS) for participants with relapsed/refractory multiple myeloma (RRMM) — Up to 5 years
Overall Survival (OS) for participants with newly-diagnosed multiple myeloma (NDMM) — Up to 8 years
Progression-Free Survival (PFS) for participants with RRMM — Up to 5 years
Progression-Free Survival (PFS) for participants with NDMM — Up to 8 years
Trial sites (130)
Facility
City
Region
Status
Local Institution
Birmingham
Alabama
Local Institute
Goodyear
Arizona
Local Institution - 0023
Anaheim
California
Local Institution
Anaheim
California
Local Institution - 0045
Burbank
California
Local Institution
Corona
California
Local Institution - 0048
Downey
California
Local Institution - 0052
Fountain Valley
California
Local Institute
Los Angeles
California
Local Institute
Santa Rosa
California
Local Institution - 0051
Santa Rosa
California
Local Institution
Brooksville
Florida
Local Institution - 0044
Fort Lauderdale
Florida
Local Institution
Jacksonville
Florida
Local Institute
Valdosta
Georgia
Local Institution - 0047
Valdosta
Georgia
Local Institution
Skokie
Illinois
Local Institution - 0041
Springfield
Illinois
Local Institution - 0058
Anderson
Indiana
Local Institution - 0011
Indianapolis
Indiana
Local Institution
Indianapolis
Indiana
Local Institute
Sioux City
Iowa
Local Institute
Louisville
Kentucky
Local Institution - 0042
Louisville
Kentucky
Local Institution
Lafayette
Louisiana
Local Institution
Shreveport
Louisiana
Local Institution
Minneapolis
Minnesota
Local Institution - 0030
Woodbury
Minnesota
Local Institute
Southaven
Mississippi
Local Institute
Kansas City
Missouri
Local Institution - 0050
Kansas City
Missouri
Local Institution - 0037
Missoula
Missouri
Local Institute
Saint Joseph
Missouri
Local Institution - 0020
Springfield
Missouri
Local Institution
Springfield
Missouri
Local Institution
St Louis
Missouri
Local Institute
Missoula
Montana
Local Institute
Missoula
Montana
Local Institute
Omaha
Nebraska
Local Institution - 0024
Omaha
Nebraska
+ 90 more sites — see the full list on the official registry below.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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