Hemophilia is an inherited bleeding disorder characterized by recurrent musculoskeletal bleeding, particularly into joints, leading to impaired physical function and reduced functional performance. The 30-Second Sit-to-Stand Test (30STS) is a simple, reliable, and valid measure of lower extremity functional performance; however, evidence regarding its performance in individuals with hemophilia remains limited. This cross-sectional observational study aims to compare 30STS performance between adults with hemophilia and age-matched healthy controls and to investigate the relationship between 30STS performance, joint health, and activity level in individuals with hemophilia. Fifty-eight participants (29 individuals with hemophilia and 29 healthy controls) aged 18-35 years will be recruited. Participants will complete the 30STS. Individuals with hemophilia will additionally undergo joint health assessment using the Hemophilia Joint Health Score (HJHS) and activity evaluation using the Hemophilia Activities List (HAL).
Eligibility
Sex
MALE
Min age
18 Years
Max age
35 Years
Healthy volunteers
Accepted
Inclusion Criteria:
Hemophilia Group:
* Diagnosis of hemophilia A or hemophilia B
* Age between 18 and 35 years
* Ability to walk independently
* Willingness to participate in the study voluntarily
Healthy Control Group:
* Age between 18 and 35 years
* No history of hemophilia or other bleeding disorders
* No history of lower extremity surgery or serious lower extremity injury within the previous 6 months
* No neurological, rheumatological, or severe orthopedic disorders
* Willingness to participate in the study voluntarily
Exclusion Criteria:
Hemophilia Group:
\- Acute joint bleeding episode within the previous 3 months
Primary outcome measure(s)
30-Second Sit-to-Stand Test Performance — Baseline assessment (single assessment visit) The primary outcome of this study is the performance on the 30-Second Sit-to-Stand Test (30STS). The test evaluates lower extremity functional performance by recording the number of correctly completed sit-to-stand repetitions within 30 seconds. The test will be performed once under standardized conditions in both the hemophilia group and healthy control group. Number of complete sit-to-stand repetitions performed from a standard chair within 30 seconds. Scores range from 0 to no fixed maximum, with higher scores indicating better lower extremity functional performance and muscle endurance.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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