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Clinical Trials in Turkey / NCT07728526
Recruiting Not applicable

The Effects of Vestibulo-Ocular Reflex Exercises Added to Postural Stabilization Training in Chronic Ankle Instability

NCT07728526 · tracked via the Priya Life Science Turkey tracker
Phase
Not applicable
Started
2026-07-22
Last updated
2026-08-10

Condition(s) studied

Ankle SprainsAnkle Sprain StrainAnkle Inversion Sprain

Investigational drug(s) / intervention(s)

Postural Stabilization TrainingVestibulo-Ocular Reflex Exercise in addition to Postural Stabilization Training

Postural Stabilization Training: Participants in this group will receive ankle joint mobilization followed by a structured postural stabilization training program. The program will include single-leg stance progression, hop stabilization tasks, and number-sequence hop tasks. Exercises will be progressed according to the participant's ability to complete each task without errors. Ankle joint mobilization will include talocrural anteroposterior mobilization and distal fibular mobilization with movement, applied before the exercise session for approximately 5 minutes. The total session will last approximately 45 minutes and will be performed 3 times per week for 6 weeks.

Vestibulo-Ocular Reflex Exercise in addition to Postural Stabilization Training: Participants in this group will receive the same ankle joint mobilization and postural stabilization training program as the Postural Stabilization Training Group. In addition, vestibulo-ocular reflex (VOR) exercises involving fixation on a visual target during head movements will be implemented. VOR exercises will be structured to progressively increase postural demands and will include sitting, standing, walking, and single-leg stance positions. The total session will last approximately 45 minutes and will be performed 3 times per week for 6 weeks.

Study summary

Chronic ankle instability (CAI) is a common condition after lateral ankle sprain. CAI is characterized by mechanical and/or functional instability, or recurrent episodes of "giving way," persisting for at least 12 months after the initial injury, and is associated with limitations in activity and participation. In amateur athletes, CAI may be overlooked or undertreated, although sport-specific activities require rapid integration of visual, vestibular, somatosensory, and cognitive information.

Postural stabilization training is commonly used to improve balance and neuromuscular control in individuals with CAI. However, individuals with CAI may show increased reliance on visual information and altered visual-vestibular sensory reweighting during postural control tasks. The vestibulo-ocular reflex (VOR) contributes to gaze stability and visual clarity during head movements and may also be related to neurocognitive processes such as attention and processing speed. This study is designed as a randomized controlled, prospective, parallel-group, pretest-posttest design trial to investigate whether VOR exercises added to postural stabilization training improve dynamic balance, functional instability, and neurocognitive performance in amateur athletes with CAI.

Eligibility

Sex
ALL
Min age
18 Years
Max age
35 Years
Healthy volunteers
No
Inclusion Criteria: * Being between 18 and 35 years of age. * Being classified as a Tier 2 athlete according to the McKay et al. Participant Classification Framework (trained/developmental level). * Having a history of at least one lateral ankle sprain (LAS) occurring at least 12 months before enrollment, resulting in swelling, pain, and functional impairment, and followed by persistent instability. * Having the most recent ankle sprain at least 3 months before study enrollment. * Having a history of recurrent ankle sprains or episodes of "giving way." * Having a diagnosis of unilateral chronic ankle instability (CAI). * Having a Cumberland Ankle Instability Tool - Turkish Version (CAIT-T) score of ≤24. * Having a Foot and Ankle Ability Measure (FAAM) score of \<90%. * Having a Foot and Ankle Ability Measure Sports subscale (FAAM-S) score of \<80%. * A side-to-side difference of ≥2.5 cm in Weight-Bearing Lunge Test distance, with the affected side demonstrating less dorsiflexion than the unaffected side. Exclusion Criteria: * History of acute lateral ankle sprain within the last 3 months. * History of lower extremity surgery. * History of acute injury to other musculoskeletal structures of the lower extremity joints within the last 3 months that affected joint integrity and function and caused interruption of desired physical activity for at least one day. * History of balance or vestibular disorders, including cerebellar, vestibular, cochlear, or inner ear dysfunction. * Visual problems that may affect the administration or interpretation of the Dynamic Visual Acuity Test, including a history of amblyopia, diplopia, or significant visual loss. * Persistent symptoms related to a previous concussion or traumatic brain injury.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Reset Fizyoterapi Istanbul Turkey (Türkiye) Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07728526 on ClinicalTrials.gov ↗ ← All trials in Turkey