HFNC Versus Microstream Advance Nasal Cannula for Oxygenation During ERCP

Condition(s) studied

Investigational drug(s) / intervention(s)

High-flow nasal canula: Heated and humidified high-flow oxygen therapy delivered through a nasal cannula during ERCP under sedation

Microstream advance nasal cannula: Oxygen support delivered through the Microstream Advance nasal cannula during ERCP under sedation.

Study summary

Endoscopic retrograde cholangiopancreatography (ERCP) procedures are commonly performed under deep sedation and are associated with a risk of hypoxemia, particularly in prone or semi-prone positions. High-flow nasal cannula (HFNC) therapy may improve oxygenation by delivering heated and humidified oxygen at high flow rates, while the Microstream Advance nasal cannula provides simultaneous nasal oxygen delivery and oral oxygen insufflation.

This prospective randomized study aims to compare the effectiveness of HFNC and Microstream Advance nasal cannula in maintaining oxygenation during ERCP procedures. Patients undergoing ERCP will be randomized into two groups receiving either HFNC or Microstream Advance nasal cannula oxygen support during sedation.

The primary outcomes are the incidence of desaturation and oxygen reserve index (ORi) measurements during the procedure. Secondary outcomes include time to achieve target ORi levels, respiratory complications, and procedure-related adverse events.

Eligibility

Primary outcome measure(s)

• Incidence of Desaturation During ERCP — During the ERCP procedure
  Comparison of the frequency of oxygen desaturation episodes between HFNC and Microstream Advance nasal cannula groups during ERCP under sedation.

Trial sites (1)

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