Respiratory Physiotherapy and Diaphragm Thickness in Ventilated ICU Patients

Condition(s) studied

Investigational drug(s) / intervention(s)

Standard ICU Physiotherapy: Standard ICU physiotherapy applied once daily for 15-20 minutes.

Neuromuscular Electrical Stimulation (NMES): NMES applied to the diaphragmatic region twice daily, in addition to standard ICU physiotherapy.

Study summary

This study aims to evaluate the effect of respiratory physiotherapy on diaphragm thickness in patients receiving mechanical ventilation support in the intensive care unit. Thinning and dysfunction of the diaphragm muscle observed during mechanical ventilation complicate the extubation process and increase the risk of respiratory failure in patients. Diaphragm dysfunction prolongs ventilator use and increases ICU mortality. The main objective of this research is to determine whether respiratory physiotherapy has protective or ameliorative effects on diaphragm muscle structure and function, to optimize the ventilator weaning process, and to provide scientific contributions to the field of respiratory rehabilitation. Changes in diaphragm thickness will be objectively evaluated using ultrasonography, and the aim is to obtain evidence-based data on the effectiveness of respiratory physiotherapy.

Eligibility

Primary outcome measure(s)

• Change in Diaphragm Thickness — Baseline (start of mechanical ventilation), Day 5, Day 7, or discharge day (whichever comes first)
  Diaphragm thickness measured by ultrasonography (high-frequency linear probe, 5-15 MHz) at the right midaxillary line between the 8th and 9th ribs in the transverse plane, at end-inspiration and end-expiration. Diaphragm Thickening Fraction (DTF) calculated as: DTF (%) = \[(Inspiratory Thickness - Expiratory Thickness) / Expiratory Thickness\] × 100

Trial sites (1)

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