Breast CancerLymph Node DissectionPostoperative PainMastectomy
Investigational drug(s) / intervention(s)
Serratus posterior superior intercostal plane blockRhomboid intercostal plane block
Serratus posterior superior intercostal plane block: Ultrasound-guided serratus posterior superior intercostal plane block (SPSIPB) performed at the upper thoracic level for postoperative analgesia following breast cancer surgery.
Rhomboid intercostal plane block: Ultrasound-guided rhomboid intercostal block (RIB) performed for postoperative analgesia following breast cancer surgery.
Study summary
This randomized clinical trial aims to evaluate and compare the analgesic efficacy of the Serratus Posterior Superior Intercostal Plane (SPSIP) and Rhomboid Intercostal Block in patients undergoing Breast Cancer Surgery With Axillary Lymph Node Dissection. The primary outcome is Visual Analog Scale (VAS) during the first 24 hours after surgery. Secondary outcomes include total opioid consumption, requirement for rescue analgesia, block performance time, block-related and systemic side effects (hematoma, pneumothorax, local anesthetic toxicity, vascular puncture, infection), Patient satisfaction assessed using a Likert scale, quality of recovery assessed using the QoR-15 questionnaire.
Eligibility
Sex
FEMALE
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria:
* Female patients aged 18-65 years
* ASA physical status I-III
* Scheduled for elective breast cancer surgery with axillary lymph node dissection
* Body mass index (BMI) between 18 and 35 kg/m²
* Ability to understand and use the patient-controlled analgesia (PCA) device
* Ability to provide written informed consent
Exclusion Criteria:
* Refusal to participate
* Allergy to local anesthetics
* Infection at the injection site
* Coagulopathy or ongoing anticoagulant therapy
* Chronic opioid use or opioid dependence
* Severe hepatic or renal insufficiency
* Pregnancy or breastfeeding
* Cognitive impairment or inability to communicate pain scores
* Body mass index (BMI) \<18 or \>35 kg/m²
Primary outcome measure(s)
postoperative pain intensity (VAS score) — 0, 1, 4, 8, 12, and 24 hours after surgery Postoperative pain will be assessed using the visual analog scale (VAS), ranging from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Higher scores represent greater pain intensity. Measurements will be recorded at predefined time points within the first 24 hours after surgery.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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