Circulating microRNAs and Response to Neoadjuvant Chemotherapy in Breast Cancer

NCT07289282 · tracked via the Priya Life Science Turkey tracker

Sponsor

Atlas University

Phase

Observational

Started

2025-12-15

Last updated

2026-03-31

Condition(s) studied

Breast CancerNeoadjuvant TherapyPathological ResponseInvasive Breast CarcinomaMicroRNAs

Study summary

This prospective observational study aims to investigate subtype-specific circulating microRNAs (miRNAs) and their association with response to neoadjuvant chemotherapy (NAC) in patients with breast cancer. Serum samples will be collected before NAC and prior to surgery, and changes in miRNA expression levels will be evaluated. Pathological complete response (pCR) and Miller-Payne scoring will be used to assess treatment response after NAC. The study also explores whether changes in circulating miRNA profiles can predict treatment response across different breast cancer subtypes. The findings may help identify biomarkers that support treatment planning and personalized therapy strategies.

Eligibility

Sex

FEMALE

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Histologically confirmed breast cancer * Planned to receive neoadjuvant chemotherapy * Biologically female * Age ≥ 18 years * Ability to provide informed consent * Adequate organ function to receive standard NAC (based on routine clinical evaluation) Exclusion Criteria: * Presence of metastatic disease at diagnosis * Prior systemic chemotherapy for breast cancer * Pregnancy or breastfeeding * Active infection or uncontrolled comorbid conditions interfering with study participation * Any condition preventing collection of blood samples

Primary outcome measure(s)

Change in circulating microRNA expression levels before and after neoadjuvant chemotherapy — Baseline (before NAC) and pre-surgery (after completion of NAC)
Quantitative assessment of selected serum microRNAs (miR-200a/b/c, miR-34a, miR-221/222, miR-155, miR-146a) using RT-PCR. Changes in expression levels will be compared between baseline and pre-surgery samples.

Trial sites (1)

Facility	City	Region	Status
Istanbul Atlas University Faculty of Medicine	Istanbul	Turkey (Türkiye)	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07289282 on ClinicalTrials.gov ↗ ← All trials in Turkey