🇮🇪Ireland
16°C Partly Cloudy · Dublin
Live Updates
--:--:-- IST
Writer Login
Latest
Clinical Trials in India / NCT05827016
Active, not recruiting Phase 3

A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma

NCT05827016 · tracked via the Priya Life Science India tracker
Sponsor
Bristol-Myers Squibb
Phase
Phase 3
Started
2023-06-22
Last updated
2026-09-17

Condition(s) studied

Multiple Myeloma

Investigational drug(s) / intervention(s)

IberdomideLenalidomide

Iberdomide: Specified dose on specified days

Lenalidomide: Specified dose on specified days

Study summary

The purpose of this study is to compare the effectiveness of iberdomide maintenance to lenalidomide maintenance therapy after autologous stem cell transplantation (ASCT) in participants with newly diagnosed multiple myeloma (NDMM).

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria * Confirmed diagnosis of symptomatic multiple myeloma (MM). * Eastern Cooperative Oncology Group performance status (ECOG) score of 0, 1, or 2. * Received 3 to 6 cycles of an induction therapy that includes a proteasome inhibitor (PI) and immunomodulatory (IMiD) \[eg, bortezomib thalidomide and dexamethasone (VTd), lenalidomide, bortezomib and dexamethasone (RVd)\] with or without a CD38 monoclonal antibody, daratumumab + bortezomib/thalidomide/dexamethasone \[D-VTd\] and daratumumab + bortezomib/ lenalidomide/dexamethasone \[D-VRd\]), or VCd / daratumumab + bortezomib/cyclophosphamide/dexamethasone \[D-VCd\], and followed by a single or tandem autologous stem cell transplantation (ASCT). Post-stem cell transplant consolidation is permitted. * Participants within 12 months (single transplant) or 15 months (tandem transplant) from initiation of induction therapy who achieved at least a partial response (PR) after autologous stem cell transplantation (ASCT) with or without consolidation, according to International Myeloma Working Group (IMWG 2016) criteria. Exclusion Criteria * Progressive disease or clinical relapse (as defined by IMWG response criteria) following ASCT with or without consolidation or is not responsive to primary therapy. * Smoldering myeloma, solitary plasmacytoma or nonsecretory myeloma. * Known central nervous system/meningeal involvement of MM. * Prior history of malignancies, other than MM, unless the participant has been free of the disease for ≥ 5 years. * Other protocol-defined Inclusion/Exclusion criteria apply.

Primary outcome measure(s)

Trial sites (269)

FacilityCityRegionStatus
Local Institution - 0202 Aurora Colorado
Local Institution - 0007 Jacksonville Florida
Local Institution - 0308 Tampa Florida
Local Institution - 0192 Tampa Florida
Local Institution - 0003 Weston Florida
Local Institution - 0019 Athens Georgia
Local Institution - 0018 Atlanta Georgia
Local Institution - 0021 Augusta Georgia
Local Institution - 0237 Chicago Illinois
University of Kansas Cancer Center - The Richard and Annette Bloch Cancer Care Pavilion Westwood Kansas
Local Institution - 0205 Clinton Maryland
Local Institution - 0279 Worcester Massachusetts
Local Institution - 0001 Ann Arbor Michigan
Local Institution - 0257 Detroit Michigan
Local Institution - 0296 Grand Rapids Michigan
Local Institution - 0303 Rochester Minnesota
Local Institution - 0207 Hattiesburg Mississippi
Local Institution - 0191 Morristown New Jersey
Local Institution - 0328 Brooklyn New York
Local Institution - 0288 Mineola New York
Local Institution - 0180 New York New York
Local Institution - 0020 New York New York
Local Institution - 0274 Westbury New York
Local Institution - 0331 Charlotte North Carolina
Local Institution - 0005 Charlotte North Carolina
Local Institution - 0281 Durham North Carolina
Local Institution - 0286 Winston-Salem North Carolina
Local Institution - 0322 Winston-Salem North Carolina
Local Institution - 0238 Cincinnati Ohio
Local Institution - 0299 Cleveland Ohio
Local Institution - 0002 Cleveland Ohio
Local Institution - 0017 Kansas Ohio
Local Institution - 0301 Mayfield Heights Ohio
Local Institution - 0013 Toledo Ohio
Local Institution - 0300 Wooster Ohio
Local Institution - 0203 Eugene Oregon
Local Institution - 0012 Philadelphia Pennsylvania
Local Institution - 0011 Philadelphia Pennsylvania
Local Institution - 0253 Pittsburgh Pennsylvania
Local Institution - 0294 Germantown Tennessee

+ 229 more sites — see the full list on the official registry below.

On this site

📄 Revlimid (lenalidomide) drug profile →

More Bristol-Myers Squibb trials in India

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05827016 on ClinicalTrials.gov ↗ ← All trials in India