AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure

NCT06650995 · tracked via the Priya Life Science Germany tracker

Sponsor

Technical University of Munich

Phase

Not applicable

Started

2027-02-01

Last updated

2026-09-18

Condition(s) studied

HFpEF - Heart Failure With Preserved Ejection FractionAtrial Fibrillation

Investigational drug(s) / intervention(s)

Exercise training

Exercise training: exercise intervention will consist of supervised, home-based, combined training with elements of endurance, resistance and respiratory training

Study summary

The investigators analyze the impact of exercise and ablation in patients with symptomatic short-persistent atrial fibrillation (Afib) and heart failure with preserved ejection fraction (HFpEF). It is hypothesized that the combination of ablation and exercise better improves peak oxygen consumption (VO2peak) through improvement of peripheral (exercise training) and central (ablation) adaptations.

Exercise intervention will contain a 12-week combined, video-based, supervised, endurance, resistance and respiratory training.

Eligibility

Sex

ALL

Min age

18 Years

Max age

99 Years

Healthy volunteers

Inclusion Criteria: * Diagnosed heart failure with preserved ejection fraction * Symptomatic short-persistent atrial fibrillation (diagnosis within 1 year of study inclusion) Exclusion Criteria: * Paroxysmal, long-persistent or permanent atrial fibrillation * Clinically unstable coronary artery disease or acute coronary syndrome * Physical and/or mental inability to perform exercise testing * Prior ablation therapy * Precapillary pulmonary hypertension at rest * Intracardiac shunts * Left ventricular ejection fraction \<50% * High-degree valve insufficiency or stenosis (greater than grade 1 at rest)

Primary outcome measure(s)

Delta of peak oxygen consumption — 14 weeks
Improvement of peak oxygen consumption between baseline and after 12 weeks of training

Trial sites (1)

Facility	City	Region	Status
Department of Medicine, Division of Prevention and Sports Medicine TU Munich	Munich	Germany	Recruiting

More Technical University of Munich trials in Germany

Blood Flow Restriction Training For The Treatment Of Lateral Epicondylopathy Recruiting

Prehabilitation in Childhood Soft Tissue or Bone Sarcomas Active, not recruiting

LLM-Generated Plain-Language Patient Synopses to Improve Comprehension in Hematology and Oncology (oncOPAL) Recruiting

Mavacamten Enables Exercise in Hypertrophic Obstructive Cardiomyopathy Recruiting

Covid-19 Predictors: Safety of Gynecological Oncology Patients Undergoing Systemic Cancer Therapy Active, not recruiting

Other trials for the same condition

Non-invasive Differentiation of Supraventricular Tachyarrhythmia Recruiting

Clinical Cohort Study - TRUST Recruiting

Early Treatment of Atrial Fibrillation for Stroke Prevention Trial in Acute STROKE Recruiting

VOLT CE Mark Study Active, not recruiting

Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06650995 on ClinicalTrials.gov ↗ ← All trials in Germany