LONGitudinal Multi-omics Phenotyping of KIDney Function Alteration

NCT05570929 · tracked via the Priya Life Science Germany tracker

Sponsor

Charite University, Berlin, Germany

Phase

Observational

Started

2023-02-07

Last updated

2024-07-01

Condition(s) studied

Chronic Kidney Diseases

Study summary

This is a longitudinal observation of kidney function, immune system and gut microbiota before and 24 weeks after a live kidney transplantation conducted in donor and recipient pairs living in the same household. Outcome measures include kidney function, body composition, blood pressure, gut microbiome composition, metabolomics and immune cell states.

Eligibility

Sex

ALL

Min age

18 Years

Max age

75 Years

Healthy volunteers

Accepted

Inclusion Criteria: * Body-Mass-Index 18,5 - 34,9 kg/m2 * Planned living kidney donation / transplantation Exclusion Criteria: * Clinically relevant heart, lung, liver, and kidney diseases * Postoperative phase * Acute infections * Vegan diet * Change of body weight of more than 10% in the month prior to study entry * Known drug or alcohol abuse

Primary outcome measure(s)

Fecal microbiome taxonomy (Shannon-Index) — Change from Baseline at 24 weeks
Measured by 16S amplicon sequencing

Trial sites (1)

Facility	City	Region	Status
Experimental and Clinical Research Center	Berlin	Germany	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05570929 on ClinicalTrials.gov ↗ ← All trials in Germany