The Oxford Risk Factors And Non-Invasive Imaging Study

NCT05169333 · tracked via the Priya Life Science Germany tracker

Sponsor

University of Oxford

Phase

Observational

Started

2016-02-23

Last updated

2026-07-31

Condition(s) studied

Cardiovascular DiseasesCardiovascular Risk Factors

Study summary

ORFAN is a prospective, multi-centre, multi-ethnic cohort observational study collecting CT scans, biological material and outcomes data, to develop and validate novel biomarkers of cardiometabolic and other disease risk.

Eligibility

Sex

ALL

Min age

18 Years

Max age

99 Years

Healthy volunteers

Inclusion Criteria: Inclusion Criteria for study Arms 1, 2 and 3: * Participant is willing and able to give informed consent for participation in the study. * Male or Female, aged 18 -99 years. Inclusion Criteria for study Arm 4: • Male or Female, aged 18 -99 years. Exclusion Criteria: Exclusion Criteria for Study Arms 1, 2 and 3: * Unable or unwilling to consent * Active cancer Exclusion Criteria for Study Arm 4: * Participation in Study Arms 1, 2 or 3 * Existing opt-out from use of data for research purposes

Primary outcome measure(s)

Cardiac and all cause mortality — 15 years
Using novel image analysis methods, clinical risk factors, and blood biomarkers to predict future cardiac and all-cause mortality over a period of 15 years post CT scan.
Non-fatal vascular events — 15 years
Using novel image analysis methods, clinical risk factors, and blood biomarkers to predict future non-fatal vascular events over a period of 15 years post CT scan.
Cardiac and non-cardiac findings by Computed Tomography — 15 years
Using novel image analysis methods, clinical risk factors, and blood biomarkers to detect pathology from Computed Tomography images.
Progression of disease — 15 years
Using novel image analysis methods, clinical risk factors, and blood biomarkers to predict progression of cardiometabolic diseases over a period of 15 years post index CT scan.

Trial sites (45)

Facility	City	Region	Status
Valleywise Health	Phoenix	Arizona	Recruiting
Yale University, School of Medicine	New Haven	Connecticut	Recruiting
Bridging Medical Silos	Tampa	Florida	Recruiting
Emory University	Atlanta	Georgia	Recruiting
Midwest Heart & Vascular Specialists LLC	Kansas City	Kansas	Recruiting
St Luke's Hospital	Kansas City	Kansas	Recruiting
NIH National Heart, Lunch, and Blood Institute	Bethesda	Maryland	Recruiting
Brigham and Women's Hospital	Boston	Massachusetts	Recruiting
Cleveland Clinic	Cleveland	Ohio	Recruiting
UT Southwestern Medical Center	Dallas	Texas	Recruiting
Brooke Army Medical Center (BAMC)	San Antonio	Texas	Recruiting
University of Virginia	Charlottesville	Virginia	Recruiting
The University of Sydney	Sydney	Australia	Not Yet Recruiting
University Hospitals Leuven	Leuven	Belgium	Not Yet Recruiting
Nicosia Polyclinic	Nicosia	Cyprus	Recruiting
GØdstrup Regional hospital	Aarhus	Denmark	Recruiting
Assistance Publique - Hôpitaux de Paris	Paris	France	Recruiting
Friedrich-Alexander-Universitat Erlangen-Nurmberg	Erlangen	Germany	Recruiting
University Hospital Ulm	Ulm	Germany	Not Yet Recruiting
Lefkos Stavros Clinic	Athens	Greece	Recruiting
National and Kapodistrian University of Athens - Hippokration Hospital	Athens	Greece	Recruiting
Semmelweis University	Budapest	Hungary	Recruiting
Centro Cardiologico Monzino IRCCS, University of Milan	Milan	Italy	Recruiting
Isola Tiberina-Gemelli Isola Hospital	Roma	Italy	Recruiting
University of Medicine and Pharmacy of Targu Mures	Târgu Mureş	Romania	Recruiting
Seoul National University	Seoul	South Korea	Recruiting
Taiwan Kaohsiung Medical University	Kaohsiung City	Taiwan	Recruiting
Royal United Hospitals Bath NHS Foundation Trust	Bath	United Kingdom	Recruiting
Sandwell and West Birmingham Hospitals NHS Trust	Birmingham	United Kingdom	Recruiting
University Hospitals Birmingham NHS Trust	Birmingham	United Kingdom	Not Yet Recruiting
Royal Papworth Hospital NHS Trust	Cambridge	United Kingdom	Recruiting
University of Edinburgh, Royal Infirmary	Edinburgh	United Kingdom	Not Yet Recruiting
Golden Jubilee National Hospital	Glasgow	United Kingdom	Not Yet Recruiting
NHS Greater Glasgow and Clyde	Glasgow	United Kingdom	Not Yet Recruiting
Leeds Teaching Hospitals NHS Trust	Leeds	United Kingdom	Recruiting
University Hosptials of Leicester NHS Trust	Leicester	United Kingdom	Recruiting
Liverpool heart and chest hospital	Liverpool	United Kingdom	Not Yet Recruiting
Barts Health NHS Trust	London	United Kingdom	Recruiting
Guy's and St Thomas' NHS Foundation Trust	London	United Kingdom	Recruiting
Royal Brompton and Harefield Hospitals	London	United Kingdom	Recruiting

+ 5 more sites — see the full list on the official registry below.

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05169333 on ClinicalTrials.gov ↗ ← All trials in Germany