The Effect of Dronabinol on the Acquisition and Consolidation of Trauma-Associated Memories

Condition(s) studied

Investigational drug(s) / intervention(s)

Dronabinol: Dronabinol

Placebo: Placebo

Study summary

The aim of the current project is to investigate the impact of an activation of the cannabinoid system with an exogenous cannabinoid dronabinol (delta-9-tetrahydrocannabinol) on the formation of intrusive memories after analog trauma.

A well-established stress-film paradigm will be used to induce intrusive symptoms in healthy participants. In a double-blind placebo-controlled study, the impact of exogenous dronabinol on intrusive symptoms during exposure to a trauma film will be examined. The primary hypothesis is that exogenous oral dronabinol will decrease the number of intrusive memories recorded in the four days following experimental trauma compared with placebo controls.

This project will contribute to the current understanding of intrusive memory formation in PTSD and may guide the development of future pharmacological preventions.

Eligibility

Primary outcome measure(s)

• Change of Intrusive Memories in the following four days after the intervention — four consecutive days
  Influence of dronabinol on the development of intrusive memories measured with an intrusion diary

Trial sites (1)

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