Data on prevention of perioperative neurocognitive disorders (pNCDs) are limited. The purpose of this monocentric parallel - grouped observational registry is to collect study data from studies with pNCDs as primary or secondary endpoint to estimate prevalence and incidence of pNCDs.
Eligibility
Sex
ALL
Min age
18 Years
Max age
100 Years
Healthy volunteers
Accepted
Study Group
Inclusion Criteria:
* Age 18 -100 years
* Male or female patients undergoing elective surgery expected to last at least 60 min, screened at the Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, Berlin, Germany
* Written informed consent to participate after having been properly instructed
Exclusion Criteria:
* Lacking willingness to take part in the study, or to have relevant study data collected, saved and analyzed for the purpose of the study
* Accommodation in an institution due to an official or judicial order
* Insufficient knowledge of German language
* Members of the hospital staff
* Homelessness or other conditions that disable reachability for postoperative assessment by post or telephone
* Illiteracy
* Patients who had a history of neurologic deficits (e.g. stroke, history of seizures, etc.)
* Hearing impairment that severely affects the neuropsychological testing.
* Visual impairment that severely affects the neuropsychological testing.
* Participation in other prospective clinical interventional trials
Control Group
Inclusion Criteria:
* Age 18 - 100 years
* Male or female patients (ASA Status I, II+III)
* No planned surgery during the next 3 months
* No surgery during the past 6 months before study inclusion
* Written informed consent to participate after having been properly instructed
Exclusion Criteria:
* Insufficient knowledge of German language Lacking willingness to take part in the study, or to have relevant study data collected, saved and analyzed for the purpose of the study
* Neuropsychiatric conditions that severely affect the neuropsychological testing
* Hearing impairment that severely affects the neuropsychological testing
* Visual impairment that severely affects the neuropsychological testing
Primary outcome measure(s)
Neurocognitive Disorder (NCD) — Up to 1 year Mild / major neurocognitive disorder 3 (mild / major NCD 'Postoperative cognitive dysfunction (POCD)') and 12 months (mild / major NCD) postoperatively.
Postoperative cognitive dysfunction (POCD) — Up to 1 year Postoperative cognitive dysfunction (POCD) is defined as relevant change in postoperative cognitive performance compared to baseline (preoperative) cognitive performance.
Trial sites (2)
Facility
City
Region
Status
Irmgard Landgraf
Berlin
Germany
Not Yet Recruiting
Department of Anesthesiology and Operative Intensive Care Medicine Berlin (CCM, CVK), Charité - Universitätsmedizin Berlin
Berlin
Germany
Recruiting
More Charite University, Berlin, Germany trials in Germany
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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