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Clinical trial register · European Union · CTIS

Obesity Clinical Trials in the EU, 2026

The most recently authorised trials on the EU Clinical Trials Information System (CTIS), the single register for every trial run under the EU Clinical Trials Regulation (536/2014). CTIS holds a far larger historical archive than any one list can usefully show โ€” this register states both numbers rather than picking one.

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Source: EMA Clinical Trials Information System (CTIS). Showing the 2500 most recently authorised of 12490 total CTIS records โ€” a stated recency window, not the full historical archive. Synced 25 Sep 2026, 03:16 UTC
2500
Shown in this register
most recently authorised
12,490
Total on CTIS
full historical archive
741
Phase III
within the shown window
Top member states
Spain 1016 France 881 Germany 860 Italy 735 Poland 585 Netherlands 531
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Trials for Obesity

15 of 2500 shown studies
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Phase
Study
Lead sponsor
Area
Member states
Decision
Phase IV
A Phase IV, Randomized Controlled Trial to Evaluate the Effects of Resistance Training Versus Usual Care on Thigh Muscle Volume During Treatment with the Dual GIP/GLP-1 Receptor Agonist Tirzepatide in Adults with Obesity
2026-526200-69-00Obesity
Klinikum der Technischen Universitaet Muenchen (TUM Klinikum)
Nutritional and Metabolic Diseases
Germany
04/08/2026
Phase IV
A neuropsychobiological approach to optimize patient selection for GLP-1-based pharmacotherapy for weight management across the binge eating spectrum
2026-526016-36-00obesity
UZ Leuven
Nutritional and Metabolic Diseases
Belgium
08/06/2026
Phase I
A research study to see how NNC0487-0111 affects the bodyโ€™s energy use after a weight loss in adults living with obesity, compared to a low-calorie diet or placebo
2025-522744-40-00Obesity
Novo Nordisk A/S
Nutritional and Metabolic Diseases
Netherlands, Denmark
11/05/2026
Phase III
Efficacy and safety of NNC0487-0111 s.c. once-weekly in participants with obesity (AMAZE 1)
2024-520440-42-00Obesity
Novo Nordisk A/S
Nutritional and Metabolic Diseases
Denmark, France, Germany, Belgium
04/05/2026
Phase III
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of KAI-9531 Administered Once Weekly in Participants Living with Obesity or Overweight and Diabetes
2025-523510-87-00Obesity
Kailera Therapeutics Inc.
Nutritional and Metabolic Diseases
Hungary, Poland, Bulgaria, Germany, Czechia, Spain
04/05/2026
Phase III
Efficacy and safety of NNC0487-0111s.c once weekly in participants with obesity who have reached target dose during run-in period (AMAZE12).
2025-523804-62-00Obesity
Novo Nordisk A/S
Nutritional and Metabolic Diseases
Belgium, Germany, Bulgaria, France, Spain, Denmark, Italy, Netherlands
27/04/2026
Phase I
A research study to compare blood levels of cagrilintide after multiple doses of different versions of cagrilintide in adults with overweight or obesity
2025-521384-12-00obesity
Novo Nordisk A/S
Nutritional and Metabolic Diseases
Germany
21/04/2026
Phase III
EVALUATING THE EFFICACY AND SAFETY OF MET097, A FULLY- BIASED ULTRA LONG-ACTING GLP-1 RA IN PEOPLE WITH OVERWEIGHT OR OBESITY AND TYPE 2 DIABETES: A PHASE 3, MULTI-CENTER RANDOMIZED PLACEBO-CONTROLLED TRIAL (VESPER-5)
2025-523975-48-00Obesity
Metsera Inc.
Nutritional and Metabolic Diseases
Czechia, Bulgaria, Slovakia, Spain, Hungary, Germany, Romania, Poland
16/04/2026
Phase I
A research study looking into how cagrilintide influences food intake and appetite in people with overweight or obesity
2025-524206-15-00Obesity
Novo Nordisk A/S
Nutritional and Metabolic Diseases
Germany
02/04/2026
Phase III
EVALUATING THE EFFICACY AND SAFETY OF MET097, A FULLY- BIASED ULTRA LONG-ACTING GLP-1RA IN PEOPLE WITH OVERWEIGHT OR OBESITY: A PHASE 3, MULTI-CENTER RANDOMIZED, CONTROLLED TRIAL (VESPER-4)
2025-523974-18-00Obesity
Metsera Inc.
Nutritional and Metabolic Diseases
Germany, Hungary, Slovakia, Poland, Spain, Czechia, Romania, Bulgaria
02/04/2026
Phase IV
Efficacy and safety of pharmacological therapy of obesity in liver transplant candidates
2026-526044-12-00Obesity
Institute For Clinical And Experimental Medicine
Digestive System Diseases
Czechia
18/03/2026
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Cite this view

Priya Life Science (2026). EU Clinical Trials Register (CTIS), filtered. Derived from the EMA Clinical Trials Information System. Retrieved 25 September 2026. https://priyalifescience.com/clinical-trials-europe/condition/obesity

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About this register

This register is built from the EU Clinical Trials Information System (CTIS), run by the European Medicines Agency: the single register for every trial authorised under the EU Clinical Trials Regulation (536/2014). CTIS held 12,490 trial records at the last sync on 25 Sep 2026, 03:16 UTC; this register shows the 2,500 most recently authorised of them, a stated recency window rather than the full archive. The list can be downloaded as CSV or JSON.

This page shows the 15 of those trials with a site in Obesity.

How many recently authorised EU trials have a site in Obesity?

15 of the 2,500 most recently authorised trials in this register list a site in Obesity; 7 of them are Phase III. Trials are counted by authorisation on CTIS, not by recruitment status, which CTIS does not publish in the same form as ClinicalTrials.gov.

Summary by phase

Trials by phase (Obesity), 15 trials
PhaseTrialsShare
Phase III746.7%
Phase IV426.7%
Phase I320%
Phase I/II16.7%

Most active sponsors

Lead sponsors with the most trials (Obesity)
Lead sponsorTrials
Novo Nordisk A/S5
Kailera Therapeutics Inc.3
Metsera Inc.2
Institute For Clinical And Experimental Medicine1
Klinikum der Technischen Universitaet Muenchen (TUM Klinikum)1
Pila Pharma AB1
UZ Brussel1
UZ Leuven1
Listing here is informational and not medical advice; eligibility is determined by each study team. Looking for Irish sites? See the Ireland, UK or USA registers. For approved medicines, see the EMA Approvals Tracker.