Hyaluronic Acid Injection in Idiopathic Carpal Tunnel Syndrome; is it Effective as Local Corticosteroids

Condition(s) studied

Investigational drug(s) / intervention(s)

Low Molecular Weight Hyaluronic Acid: Ultrasound-guided perineural injection of low molecular weight Hyaluronic Acid.

corticosteroid: Ultrasound-guided perineural injection of corticosteroids

Study summary

This study compares the effectiveness of two types of local injections-Hyaluronic Acid (HA) and corticosteroids-for treating mild to moderate idiopathic Carpal Tunnel Syndrome (CTS). Sixty adult patients will be assigned to receive one of the two injections under ultrasound guidance. The goal is to see if HA is as effective as the standard corticosteroid treatment in improving symptoms and nerve function over a 3-month follow-up period.

Eligibility

Primary outcome measure(s)

• Change in Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) Scores — Baseline, 1 month, and 3 months post-injection
  Comparison of the BCTQ scores (symptom severity and functional status) between the Hyaluronic Acid and Corticosteroid groups.
• Change in Electro-diagnostic Parameters — Time Frame Baseline, 1 month, and 3 months post-injection
  Comparison of sensory and motor electrodiagnostic parameters between the two groups, including peak sensory latency (ms), sensory nerve action potential - SNAP (µV), sensory conduction velocity - SCV (m/s), distal motor latency (ms), compound muscle action potential - CMAP (mV), and motor conduction velocity - MCV (m/s).
• Change in Neuromuscular Ultrasound Examination Parameters — Baseline, 1 month, and 3 months post-injection
  Comparison of neuromuscular ultrasound parameters between the two groups, including the median nerve cross-sectional area (CSA) measured in mm², fascicular pattern, flattening ratio, and mobility of the median nerve.

Trial sites (1)

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