Effects of Remimazolam on Postoperative Myocardial Injury

NCT07725185 · tracked via the Priya Life Science China tracker

Sponsor

Affiliated Hospital of Jiaxing University

Phase

Not applicable

Started

2026-08-01

Last updated

2026-08-25

Condition(s) studied

Myocardial Injury

Investigational drug(s) / intervention(s)

RemimazolamPropofol

Remimazolam: Induction dose of remimazolam: 0.2-0.4 mg/kg; maintenance dose of remimazolam: 0.2-1 mg/kg/h. Maintain BIS values between 40 and 60.

Propofol: Induction dose of propofol : 1.5 -2.5mg/kg; maintenance dose of propofol : 1.5-4.5mg/kg/h. Maintain BIS values between 40 and 60.

Study summary

This study is designed as a prospective, double-blind, randomized controlled trial to investigate the effect of remimazolam on intraoperative cardiac output (CO) in elderly patients undergoing general anesthesia, and to evaluate its protective efficacy against elevated high-sensitivity cardiac troponin T (hs-cTnT) levels and perioperative myocardial injury.

Eligibility

Sex

ALL

Min age

65 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Age ≥ 65 years * Elderly hospitalized patients scheduled to undergo general anesthesia * American Society of Anesthesiologists (ASA) physical status I-III * Surgery to be performed in the supine position * Ability to communicate with the investigator and to cooperate in completing the assessment scales * Expected duration of surgery ≥ 2 hours Exclusion Criteria: * Congenital heart disease, severe cardiac conduction block, or implanted cardiac pacemaker; * History of cerebral infarction, cerebral hemorrhage, or stroke within the past 3 months; * Known allergy to remimazolam or propofol; * Severe mental illness, history of analgesic abuse, or addiction to psychotropic drugs; * Patient or family members refuse surgery or anesthesia, or are unable to complete the required questionnaires.

Primary outcome measure(s)

postoperative day 1 hs-cTnT — postoperative day 1
postoperative day 1 hs-cTnT level

Trial sites (1)

Facility	City	Region	Status
Jiaxing University Affiliated Hospital	Jiaxing	Zhejiang

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07725185 on ClinicalTrials.gov ↗ ← All trials in China