Ireland
--:--IST
Latest
Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide
Clinical Trials in China / NCT07340255
Recruiting Not applicable

The 90% Effective Ventilation Pressure (EP90) for Esophageal Insufflation Avoidance During Anesthesia Induction

NCT07340255 · tracked via the Priya Life Science China tracker
Sponsor
Affiliated Hospital of Jiaxing University
Phase
Not applicable
Started
2025-09-29
Last updated
2026-01-14

Condition(s) studied

Airway ManagementInduction of Anesthesia

Investigational drug(s) / intervention(s)

Ultrasonic and inflation determination

Ultrasonic and inflation determination: Before induction, during ventilation, and after intubation, the anesthesiologist used a 7-14 MHz linear array probe for transverse (supraclavicular) positioning to monitor the left paratracheal esophageal region in real time. The main criterion for assessment was the absence of esophageal gas during ventilation, which was considered a positive response. If gas was detected entering the esophagus on ultrasound, it was recorded as a negative response. Additionally, the anesthesiologist performed a preoperative ultrasound examination of the gastric antrum to record baseline gastric antrum parameters. After successful tracheal intubation, a follow-up ultrasound of the gastric antrum was conducted to obtain postoperative gastric antrum parameters.

Study summary

Exploring the 90% Effective Ventilation Pressure (EP90) for Esophageal Insufflation Avoidance During Anesthesia Induction: The aim is to determine the optimal ventilation pressure for esophageal insufflation avoidance during anesthesia induction and to explore its guiding significance for anesthesia management. The goal is to provide a more precise and personalized ventilation pressure setting standard for clinical anesthesia, thereby enhancing the safety of the anesthesia induction phase.

Eligibility

Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria: 1. Age: 18-65 years, regardless of gender; 2. ASA classification: I-III; 3. Scheduled for elective general anesthesia surgery; 4. BMI: 18.0-28.0 kg/m²; 5. Preoperative fasting: Solid food \>6 hours, liquid \>2 hours; 6. Less than two from five criteria predicting difficult mask ventilation as described by Langeron et al.(Prediction of difficult mask ventilation. Anesthesiology 2000; 92:1229-36); 7. No severe underlying conditions such as heart, lung, liver, or kidney disease; 8. Signed informed consent and ability to cooperate with the study protocol. Exclusion Criteria: 1. Pregnant or breastfeeding women; 2. History of upper gastrointestinal diseases such as gastroesophageal reflux disease, peptic ulcers, or hiatal hernia; 3. Recent (within 2 weeks) respiratory infections, chronic cough, similar symptoms, and other known or predictable respiratory system diseases; 4. Need for emergency surgery or airway obstruction after anesthesia induction requiring urgent intubation; 5. Inability to achieve adequate oxygenation during mask ventilation (e.g., SpO₂ \< 92% for 30 seconds, unresponsive to treatment); 6. History of contraindications or allergies to study medications; 7. Inability to understand the study content or refusal to cooperate; 8. Oropharyngeal or facial pathology; 9. with an indwelling gastric tube, and who had previously undergone gastric surgery.

Primary outcome measure(s)

  • EP90 — Perioperative
    The 90% effective ventilation pressure (EP90) for avoiding esophageal inflation refers to the minimum effective airway pressure (measured in cmH₂O) at which 90% of patients do not experience esophageal inflation during pressure-controlled mask ventilation during anesthesia induction.

Trial sites (1)

FacilityCityRegionStatus
Affiliated Hospital of Jiaxing University Jiaxing China Recruiting

More Affiliated Hospital of Jiaxing University trials in China

Effects of Remimazolam on Postoperative Myocardial Injury Enrolling by invitation
Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Myocardial Injury in Elderly Patients Undergoing Thoracoscopic Surgery: a Prospective, Randomized Controlled Study Enrolling by invitation
Effect of Optimal Biological Volume Bupivacaine Liposome Interscalene Brachial Plexus Block on Postoperative Analgesia After Shoulder Arthroscopy Enrolling by invitation
The Impact of Long-term High-risk Drinking on the Effective Dose of Osselidin Starting soon
Determination of the Optimal Volume of 0.5% Bupivacaine Liposome in Single-Injection Interscalene Brachial Plexus Block: A Bayesian Phase I/II Trial Enrolling by invitation

Other trials for the same condition

The Influence of Standardized Process Management of Laryngeal Mask Airway Placement Based on Pressure Monitoring on the Incidence of Adverse Reactions in Elderly Patients During the Perioperative Period Recruiting
3D-CT-Based Prediction of Difficult Laryngoscopy in Infants With Pierre Robin Sequence Active, not recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07340255 on ClinicalTrials.gov ↗ ← All trials in China