The Effectiveness and Safety of Combined Research on Uremic Sarcopenia

Condition(s) studied

Investigational drug(s) / intervention(s)

Received mindfulness meditation training during dialysis in addition to exercise therapy.: The SG received pre-dialysis progressive resistance training (PRT), while the IG added mindfulness meditation during dialysis.

Study summary

Objective: To investigate the clinical efficacy and safety of mindfulness meditation during dialysis combined with pre-dialysis progressive resistance training (PRT) for sarcopenia in patients undergoing maintenance hemodialysis (MHD).

Methods: In the randomized controlled trial, 76 MHD patients with sarcopenia were divided into three groups: control group (CG), sports group (SG), and intervention group (IG). All groups received standard dialysis, health education, and dietary guidance. The SG received pre-dialysis PRT, while the IG added mindfulness meditation during dialysis. Efficacy and safety were evaluated at baseline and after 12 weeks. Ultrasound assessments of muscle mass were conducted at baseline, week 4, week 8, and week 12.

Eligibility

Primary outcome measure(s)

• Change in 30-second Chair Stand Test (CS30) — 12 weeks
  The range of the test result is 0-30 repetitions. Higher values indicate better lower limb muscle strength and physical function. The change value before and after 12-week intervention is the evaluation index
• Change in Handgrip Strength — 12 weeks
  The unit of handgrip strength is kg. Higher values indicate improved upper limb muscle strength. The change value before and after 12-week intervention is the evaluation index
• Change in 6-Minute Walking Test (6MWT) — 12 weeks
  The unit of walking distance is meters. Longer walking distance indicates better exercise tolerance and physical endurance. The change value before and after 12-week intervention is the evaluation index.
• Change in Stair Climbing Test — 12 weeks
  The unit of test result is seconds. Shorter completion time indicates improved lower limb motor function. The change value before and after 12-week intervention is the evaluation index.
• Change in 10-Time Sit-to-Stand Test (TT10SU) — 12 weeks
  The unit of test result is seconds. Shorter completion time indicates better lower limb muscle function. The change value before and after 12-week intervention is the evaluation index.
• Change in Timed Up and Go Test (TUGT) — 12 weeks
  The unit of test result is seconds. Shorter completion time indicates better balance and mobility function. The change value before and after 12-week intervention is the evaluation index.
• Change in skeletal muscle thickness measured by ultrasound — 4 weeks
  The unit of skeletal muscle thickness is cm. Greater muscle thickness indicates improved muscle mass. The change value before and after 12-week intervention is the evaluation index.
• Change in quality of life assessed by standardized scale — 12 weeks
  Higher scores of the standardized quality of life scale represent improved quality of life and physical performance. The change value before and after 12-week intervention is the evaluation index.

Trial sites (1)

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