Dyclonine hydrochloride mucilage: Dyclonine hydrochloride mucilage (10 ml: 0.1 g) will be used. Each participant will hold 10 ml of the solution in the throat for 2 minutes before swallowing, 10-15 minutes prior to gastroscopy.
Tetracaine Hydrochloride Jelly: Tetracaine hydrochloride jelly (specification: 10 g : 0.1 g) will be administered 10-15 minutes prior to gastroscopy. A nurse will spray the jelly onto the root of the participant's tongue and then instruct the participant to swallow it.
Study summary
Gastroscopy is a key diagnostic approach for upper gastrointestinal diseases, but pharyngeal passage of the gastroscopy often causes participants' discomfort. Topical pharyngeal anesthetics are routinely used to alleviate such discomfort. Dyclonine hydrochloride mucilage and tetracaine hydrochloride jelly are the two most commonly used topical pharyngeal anesthetics in clinical practice. Although both agents are widely used, their comparative efficacy in unsedated gastroscopy remains unclear, and high-quality evidence is scarce. This study aims to compare their anesthetic efficacy,participant comfort, and safety.
Eligibility
Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria:
* Age 18-75 years, of either sex;
* Scheduled for an unsedated gastroscopy;
* American Society of Anesthesiologists (ASA) physical status class I or II;
* Able to understand and cooperate with Visual Analogue Scale (VAS) comfort assessment;
* Willing to provide written informed consent voluntarily.
Exclusion Criteria:
* Known allergy to the study agents;
* Severe cardiopulmonary disease or hepatic/renal insufficiency;
* Long-term use of sedatives or analgesics, or history of alcohol abuse;
* Pregnancy or lactation;
* Dysphagia or trismus (limited mouth opening);
* Contraindications to upper gastrointestinal endoscopy, including acute perforation and active massive bleeding;
* Mental or cognitive disorders that may preclude cooperation with the procedure;
* Scheduled for therapeutic endoscopic procedures with an anticipated procedure time exceeding 15 minutes;
* Altered upper gastrointestinal anatomy due to prior total gastrectomy, esophagectomy, or subtotal gastrectomy.
Primary outcome measure(s)
Visual Analogue Scale(VAS) Score — Within 5 minutes after completion of gastroscopy Using a 0-10 Visual Analogue Scale (VAS), ranging from 0 (no discomfort) to 10 (worst possible discomfort), higher scores indicate worse outcome.
Trial sites (1)
Facility
City
Region
Status
Department of Gastroenterology,General Hospital of Northern Theater Command
Shenyang
Liaoning
More General Hospital of Shenyang Military Region trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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