The Long-term Effect of Remote Ischemic Conditioning on Main Organs in ASVCD Patients With Very High Risks

Inclusion Criteria: * Age over 40 years * Two or more prior major ASCVD events; OR one documented major ASCVD event with two or more of the following risk factors * signed informed consent Note： Definition of Major ASCVD Events: A. Acute coronary syndrome within the past year. B. History of myocardial infarction (not part of a new acute coronary syndrome episode). C. Ischemic stroke or history of ischemic stroke. D. Symptomatic peripheral artery disease, defined as intermittent claudication with an ankle-brachial index (ABI) \< 0.85, or prior limb revascularization or amputation. Risk factors: 1. Age ≥65 y 2. Heterozygous familial hypercholesterolemia 3. History of prior coronary artery bypass surgery or percutaneous coronary intervention outside of the major 4. ASCVD event(s) 5. Diabetes mellitus 6. Hypertension 7. CKD (eGFR 15-59 mL/min/1.73 m2) 8. Current smoking 9. Persistently elevated LDL-C (LDL-C ≥100 mg/dL \[≥2.6 mmol/L\]) despite maximally tolerated statin therapy and ezetimibe 10. History of congestive HF Exclusion Criteria: * Presence of severe neurological deficit (mRS score ≥ 3) * Uncontrolled severe hypertension (systolic blood pressure \> 180 mmHg or diastolic blood pressure \> 110 mmHg despite medication) * Subclavian artery stenosis ≥ 50% or presence of subclavian steal syndrome * Severe hematological disorders or significant coagulation abnormalities * Contraindications to remote ischemic conditioning, such as severe soft tissue injury, fracture, or vascular injury in the upper limbs, or peripheral vascular disease in the distal upper limbs * Severe comorbid conditions with a life expectancy of less than 1 year * Participation in another clinical trial within the past 3 months or ongoing participation * Any other circumstances deemed by the investigator as unsuitable for participation in this clinical study.