Off-Pump Coronary Artery Bypass Grafting: Off-pump coronary artery bypass grafting is performed as part of routine clinical care for patients with coronary artery disease. The study protocol does not assign participants to this procedure or to any additional intervention. This observational study will collect perioperative clinical data and follow patients after surgery to assess postoperative cognitive dysfunction.
Study summary
This prospective cohort study aims to investigate postoperative cognitive dysfunction in patients undergoing off-pump coronary artery bypass grafting. Eligible patients will be enrolled before surgery and followed after surgery. Cognitive function will be assessed using the Montreal Cognitive Assessment before surgery and at predefined postoperative time points. Perioperative clinical information, including preoperative assessment data, intraoperative monitoring parameters, and postoperative clinical data, will be collected. The study will evaluate the occurrence of postoperative cognitive dysfunction and explore its association with perioperative factors.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Age 18 years or older
* Scheduled to undergo elective off-pump coronary artery bypass grafting
* American Society of Anesthesiologists physical status classification I to IV
* Able to complete preoperative cognitive assessments, including the Mini-Mental State Examination and the Montreal Cognitive Assessment
* Written informed consent provided by the patient or family member
Exclusion Criteria:
* Emergency surgery
* Pre-existing diagnosed cognitive impairment or history of psychiatric disease
* Preoperative cognitive impairment
* Severe neurological disease, such as sequelae of stroke, that may interfere with cognitive assessment
* Severe visual or hearing impairment that prevents completion of cognitive assessment
* Inability to understand Chinese or presence of language communication barriers
Primary outcome measure(s)
Incidence of Postoperative Cognitive Dysfunction — Postoperative Day 7, or 1 Day Before Hospital Discharge if Discharged Before Postoperative Day 7 Postoperative cognitive dysfunction will be evaluated by comparing postoperative Montreal Cognitive Assessment scores with preoperative baseline scores. Preoperative cognitive function will be assessed using the Montreal Cognitive Assessment 1 day after hospital admission. Postoperative cognitive function will be assessed using the Montreal Cognitive Assessment on postoperative day 7 or, if the patient is discharged before postoperative day 7, 1 day before hospital discharge. Postoperative cognitive dysfunction is defined as a decline in the postoperative Montreal Cognitive Assessment score of at least 1 standard deviation compared with the preoperative baseline score.
Trial sites (1)
Facility
City
Region
Status
Beijing Anzhen Hospital, Capital Medical University
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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