a single-injection adductor canal blockcontinuous femoral nerve block
a single-injection adductor canal block: An ultrasound-guided adductor canal block is performed via the conventional adductor canal approach. Under ultrasound guidance, 20 milliliters of 1.33% bupivacaine liposome is injected into the adductor canal.
continuous femoral nerve block: An ultrasound-guided perineural sheath block of the femoral nerve is performed via the conventional femoral nerve approach. A femoral nerve catheter is then placed and connected to an analgesia pump containing 150 milliliters of 0.20% ropivacaine.
Study summary
This study employs a randomized controlled trial to investigate whether bupivacaine liposome injection for adductor canal block can effectively improve lower limb muscle strength after total knee arthroplasty.
Eligibility
Sex
ALL
Min age
60 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria:
1. Patients aged 60-75 years scheduled for elective TKA;
2. ASA physical status classification II-III;
3. BMI 18-30 kg/m²;
4. Agreement to participate in this study and provision of signed informed consent.
Exclusion Criteria:
1. Individuals with communication barriers such as language or hearing impairments;
2. Patients with contraindications to nerve blocks;
3. Severe systemic diseases, such as severe renal disease (estimated glomerular filtration rate below 50 mL/min), cardiac disease (congestive heart failure New York Heart Association Class III to IV), or severe hepatic disease defined as a current or past diagnosis of acute/subacute hepatic necrosis, acute liver failure, chronic liver disease, liver abscess, hepatic coma, or hepatorenal syndrome;
4. History of long-term opioid use (defined as daily or nearly daily opioid use within the past 3 months).
Primary outcome measure(s)
Quadriceps Muscle Strength — 24 hours after surgery The Maximum Voluntary Isometric Contraction (MVIC) test is used to assess quadriceps strength. The tester holds a handheld dynamometer. The patient sits on the bed with legs hanging naturally, and the knee is flexed to 60°. The patient is instructed to slowly exert force to extend the knee forward. As the patient exerts force, the tester applies an equal and opposite counterforce with the dynamometer to maintain the position and angle of the lower leg. The patient sustains maximum effort for 3-5 seconds, and the peak value displayed on the dynamometer is recorded as the result for that trial. Each leg is tested 2-3 times, with a 60-90 second rest between trials to prevent muscle fatigue from affecting the results. The average value is recorded as the final outcome. The unit of measurement is Newtons (N).
Trial sites (1)
Facility
City
Region
Status
General hospital of Ningxia medical university
Yinchuan
Ningxia
More General Hospital of Ningxia Medical University trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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