Inhalational Versus Intravenous Anesthesia on Postoperative Lung Injury in Septic Patients Undergoing Surgery

NCT07601256 · tracked via the Priya Life Science China tracker

Sponsor

Sixth Affiliated Hospital, Sun Yat-sen University

Phase

Not applicable

Started

2026-08-15

Last updated

2026-05-22

Condition(s) studied

SepsisLung Injury

Investigational drug(s) / intervention(s)

Inhalation Anesthesiaintravenous anesthesia

Inhalation Anesthesia: The inhalation group will be maintained with inhaled sevoflurane and a continuous intravenous infusion of remifentanil.

intravenous anesthesia: The intravenous group will be maintained with continuous intravenous infusions of both ciprofol and remifentanil.

Study summary

This randomized controlled trial will compare the effects of intraoperative inhalational anesthesia versus intravenous anesthesia on postoperative lung injury in septic patients undergoing surgery. The primary goal is to determine if the choice of anesthetic technique influences the incidence or severity of this complication. Participants will be randomly assigned to one of the two anesthetic regimens during surgery. They will receive daily in-hospital assessments for lung injury and other outcomes and will be followed for clinical outcomes until 90 days after the procedure.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: 1. Age ≥ 18 years. 2. Diagnosis of sepsis according to Sepsis-3.0 (highly suspected or confirmed infection with acute increase in SOFA score ≥ 2). 3. Scheduled to undergo surgery under general aaesthesia for source control or sepsis-related operative management. Exclusion Criteria: 1. Already intubated prior to entering the operating room. 2. Chronic home ventilator dependence (e.g., severe chronic obstructive pulmonary disease) before surgery. 3. Personal or family history of malignant hyperthermia. 4. Known allergy to ciprofol or sevoflurane. 5. Known allergy to egg or soy products. 6. Any contraindication to the planned anaesthetic agents. 7. Pregnant women.

Primary outcome measure(s)

Ventilator-free days at 7 days after surgery — From the surgery to the 7th day

Trial sites (1)

Facility	City	Region	Status
The Sixth Affiliated Hospital of Sun Yat-sen University	Guangzhou	Guangdong

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07601256 on ClinicalTrials.gov ↗ ← All trials in China