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Clinical Trials in China / NCT07323043
Recruiting Not applicable

Effect of Tegileridine Versus Sufentanil as Analgesic Components on Opioid-Induced Cough During Anesthesia Induction

NCT07323043 · tracked via the Priya Life Science China tracker
Sponsor
The First People's Hospital of Lianyungang
Phase
Not applicable
Started
2026-01-15
Last updated
2026-07-08

Condition(s) studied

General Anesthetic Drug Adverse Reaction

Investigational drug(s) / intervention(s)

TegilerdineSufentanil →

Tegilerdine: Inject Tegilerdine in the induction of general anesthesia

Sufentanil: Inject Sufentanil in the induction of general anesthesia

Study summary

In patients undergoing general anesthesia with planned tracheal intubation , a prospective, randomized, controlled study was conducted to record the occurrence of cough 2 minutes after injection of Sufentanil or Tegilerdine. The cough was graded based on the frequency and duration: Grade I, no cough; Grade II, a single mild cough; Grade III, multiple coughs with duration \<1 second; Grade IV, continuous coughing with a duration \>15 seconds.

Eligibility

Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
Accepted
Inclusion Criteria: 1. Age between 18 and 65 years, 18 ≤ BMI (kg/m²) ≤ 30; 2. ASA grade I \~ III; 3. Scheduled elective surgery under general anesthesia with tracheal intubation. Exclusion Criteria: 1. Patients with chronic cough (cough lasting \>8 weeks) or asthma; 2. Patients with a history of allergy to the drugs used during the study; 3. Patients with severe cardiovascular disease, intracranial lesions, eye lesions, or lung lesions.

Primary outcome measure(s)

  • Incidence of choking cough response — 2 minutes after administration
    Two minutes after administration of the study drugs (Tegilerdine/Sufentanil), any clear coughing action is considered an 'occurrence'.

Trial sites (1)

FacilityCityRegionStatus
The Affiliated Lianyungang Hospital of Xuzhou Medical University Lianyungang Jiangsu Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07323043 on ClinicalTrials.gov ↗ ← All trials in China