Anesthetic Effect of Ropivacaine on Local Infiltration Anesthesia in Arteriovenous Fistula Surgery

Condition(s) studied

Investigational drug(s) / intervention(s)

Ropivacaine: 0.375% ropivacaine solution (75 mg total dose in 20 mL volume) administered as local infiltration anesthesia for arteriovenous fistula surgery

Lidocaine: 0.67% lidocaine solution (100 mg total dose in 15 mL volume) administered as local infiltration anesthesia

Study summary

This study compares two local anesthetics, ropivacaine and lidocaine, for patients undergoing arteriovenous fistula surgery. Arteriovenous fistula is the preferred vascular access for end-stage kidney disease patients needing hemodialysis.

In this clinical trial, patients are randomly assigned to receive either ropivacaine or lidocaine for local anesthesia during the surgery. Researchers are evaluating which medication provides better pain control and improves surgical outcomes.

The study is examining:

* Pain levels during and after surgery
* Surgery duration
* Need for additional pain medication
* Surgical complications
* Fistula development over time
* Long-term fistula function at 1 year and 5 years

This is a double-blind study, meaning neither patients nor surgeons know which medication is being used. The study is currently ongoing with active patient follow-up and is expected to be completed in June 2026. Patients are being followed for up to 5 years to monitor their long-term progress.

This research may help doctors choose the best local anesthetic for arteriovenous fistula surgery, potentially leading to better pain control and improved long-term outcomes for kidney disease patients.

Eligibility

Primary outcome measure(s)

• Intraoperative Pain Scores — During surgery (at the end of the procedure)
  Pain intensity assessed using 10-point Visual Analog Scale (0 = no pain, 10 = worst pain imaginable)
• Operative Time — During surgery
  Duration from skin incision to wound closure (minutes)
• Need for Supplemental Anesthesia — During surgery
  Requirement for additional anesthetic doses due to patient-reported intolerable pain after initial infiltration
• Postoperative Pain Scores — 24 hours postoperatively
  Pain intensity assessed using 10-point Visual Analog Scale
• Incidence of Postoperative Vasospasm — 48 hours postoperatively
  Development of arteriovenous fistula tremor reduction or absence within 48 hours postoperatively

Trial sites (1)

More The First People's Hospital of Lianyungang trials in China

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