This study is part of a nationwide research project in China that aims to better understand how coronary artery disease develops and progresses in young adults. The study will enroll approximately 10,000 participants aged 45 years or younger who undergo coronary CT scans at multiple hospitals across China.
Information collected at enrollment includes basic health information, cardiovascular risk factors, blood test results, medication use, lifestyle habits, and, for some participants, genetic data. Participants will undergo follow-up coronary CT scans after several years to evaluate changes in coronary artery plaque and disease progression.
By analyzing these clinical and imaging data, the study aims to identify factors associated with disease progression and to develop prediction models that may help estimate an individual's future risk of coronary plaque progression and cardiovascular events. The results of this study may contribute to improved risk assessment and early prevention strategies for coronary artery disease in young populations.
Eligibility
Sex
ALL
Min age
18 Years
Max age
45 Years
Healthy volunteers
No
Inclusion Criteria:
1. Age between 18 and 45 years at the time of enrollment.
2. Presence of symptoms suggestive of coronary artery disease and completion of coronary computed tomography (CT) examination.
3. Ability and willingness to provide written informed consent and to participate in follow-up assessments.
Exclusion Criteria:
1. Inability or unwillingness to complete follow-up assessments.
2. Inability to provide written informed consent.
3. History of coronary revascularization, including percutaneous coronary intervention or coronary artery bypass grafting.
4. Poor-quality coronary computed tomography images that are inadequate for reliable plaque assessment.
5. Presence of severe systemic disease with limited life expectancy that may interfere with study follow-up.
6. Pregnant or breastfeeding women.
7. Participation in another clinical study that may interfere with the outcomes of this study.
Primary outcome measure(s)
Progression of Coronary Plaque on Computed Tomography — From baseline to follow-up coronary CT, up to 3 years Progression of coronary atherosclerotic plaque assessed by comparing baseline and follow-up coronary computed tomography scans.
Trial sites (1)
Facility
City
Region
Status
FuWai hospital
Beijing
China
Recruiting
More Fu Wai Hospital, Beijing, China trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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