Evaluation of Plasma Non-coding RNAs as Biomarkers in Coronary Heart Disease

Inclusion Criteria: 1. 18 years of age or older; 2. the most recent symptoms of coronary heart disease within 7 days; 3. meet one of the following conditions: A. clinical history of typical ischemic chest pain (more than 5 minutes of persistent chest pain); B. serum cardiac biomarkers positive (TnT/I or creatine kinase peak greater than 99% of URL); C. Electrocardiogram changes of myocardial ischemia. Exclusion Criteria: 1. pregnant women or plan to; 2. participate in any drug clinical trials within 3 months; 3. patients with life-threatening complications, or the researchers determined that the survival time of patients with no more than 1 years; 4. serious neurological disease (Alzheimer's disease, Parkinson syndrome, progressive lower limbs or deaf patients); 5. previous history of cancer or tumor, or pathological examination confirmed precancerous lesions (such as breast ductal carcinoma in situ, or atypical hyperplasia of the cervix); 6. patients refused to comply with the requirements of this study to complete the research work; 7. according to the researchers, patients can not complete the study or not to comply with the requirements of this study (because of the reasons for the management or other reasons).