exposure to organic pollutant: Small samples of subcutaneous and visceral adipose tissue will be analyzed for the presence and concentration of specific organic pollutants using validated analytical chemistry methods, such as gas chromatography-mass spectrometry (GC-MS) or liquid chromatography-mass spectrometry (LC-MS).
Study summary
This study looks at whether certain environmental chemicals, called organic pollutants, build up in the body fat and stomach tissues of people with obesity who are having weight-loss (bariatric) surgery. These pollutants can come from things like plastics, pesticides, or industrial waste, and may affect health in different ways.
The investigators will measure the amount of these pollutants in tissue samples taken during surgery and see if the levels are different in people with mild, moderate, or severe obesity. By understanding these patterns, the investigators hope to learn more about how environmental factors may influence obesity and related health problems. The findings could help guide future prevention and treatment strategies for patients.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Adults ≥18 years.
* BMI ≥30 kg/m² at screening (measured within 30 days before surgery).
* Scheduled for primary bariatric surgery (e.g., sleeve gastrectomy or Roux-en-Y gastric bypass) for clinical indications.
* Able to provide informed consent.
* Willing to allow intraoperative collection of subcutaneous/visceral adipose tissue and gastric tissue for pollutant analysis.
* Availability of basic preoperative clinical data (demographics, comorbidities, relevant labs).
Exclusion Criteria:
* Prior bariatric or major upper gastrointestinal surgery that alters stomach/anatomy relevant to sampling.
* Pregnant or breastfeeding at screening or on day of surgery.
* Active malignancy (excluding non-melanoma skin cancers) or ongoing systemic immunosuppressive therapy (e.g., chronic corticosteroids, biologics) within 3 months.
* Severe organ dysfunction: decompensated cirrhosis (Child-Pugh C) or eGFR \<30 mL/min/1.73m².
* Acute infection or decompensated chronic illness that would preclude elective surgery per treating team.
* Documented high-level occupational or accidental chemical exposure within 6 months (e.g., pesticide poisoning) likely to bias tissue pollutant measurements.
* Participation in another interventional study expected to affect weight or metabolism within 3 months.
* Inadequate tissue obtainable at surgery for analysis (determined intraoperatively by the investigators).
Primary outcome measure(s)
Obesity Severity — At baseline (within 1 month before bariatric surgery). The investigators will assess obesity severity based on body mass index (BMI), calculated as body weight in kilograms divided by height in meters squared (kg/m²). BMI will be obtained using standardized measurements of height and weight during the preoperative evaluation. Obesity severity will be categorized according to World Health Organization (WHO) criteria (Class I: 30.0-34.9 kg/m², Class II: 35.0-39.9 kg/m², Class III: ≥ 40.0 kg/m²).
Trial sites (1)
Facility
City
Region
Status
The First Affiliated Hospital of Chongqing Medical University
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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