Novel Biomarkers and Postoperative Kidney Injury in Radical Nephrectomy

NCT07088874 · tracked via the Priya Life Science China tracker

Sponsor

Peking University First Hospital

Phase

Observational

Started

2025-08-02

Last updated

2025-09-08

Condition(s) studied

NephrectomyAcute Kidney InjuryBiomarker

Study summary

The incidence of acute kidney injury (AKI) after radical nephrectomy exceeds 40%. Currently, the KDIGO criteria are the recognized diagnostic standard for AKI. These criteria primarily use serum creatinine and urine output as key indicators, but both parameters have certain limitations, such as delayed response, insensitivity, and inaccuracy. This study aims to simultaneously monitor perioperative novel renal damaging, stressful, and functional biomarkers in patients undergoing radical nephrectomy, and to investigate their predictive value for AKI and postoperative 1-year chronic kidney disease (CKD).

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Age ≥18 years; * Scheduled to undergo unilateral radical nephrectomy. Exclusion Criteria: * Solitary kidney; * Preoperative diagnosis of chronic kidney disease stages G4 or G5 (GFR \<30 mL/min/1.73m²); * Tumor invasion of the vena cava requiring thrombectomy; * Other conditions deemed by the investigator as unsuitable for participation in this study.

Primary outcome measure(s)

The urinary [TIMP-2]×[IGFBP-7], urinary NGAL, urinary KIM-1, serum cystatin C and their combinations to predict postoperative AKI occurring within 7 days. — Up to 7 days after surgery.
Novel biomarkers above were collected at the end of surgery, and at postoperative 1h, 6h, and 20h. AKI diagnosed according to 2012 KDIGO criteria (occurring within 7 days after surgery).

Trial sites (1)

Facility	City	Region	Status
Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital	Beijing	Beijing Municipality	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07088874 on ClinicalTrials.gov ↗ ← All trials in China