Phase II Study of QLS32015 Combination Therapy in the Treatment of Multiple Myeloma

Inclusion Criteria: * Diagnosis of multiple myeloma confirmed according to the 2016 International Myeloma Working Group (IMWG) diagnostic criteria; * Prior therapy: Relapsed, progressed, or intolerant to ≥1 prior line of anti-multiple myeloma therapy; * Measurable disease at screening, defined by at least one of the following: * Serum M-protein ≥1.0 g/dL (10 g/L); * Urine M-protein ≥200 mg/24 hours; * Serum immunoglobulin free light chain ≥10 mg/dL (100 mg/L) with an abnormal serum immunoglobulin κ/λ free light chain ratio. Exclusion Criteria: * History of Grade 3 or higher cytokine release syndrome (CRS) associated with any T-cell redirecting therapy (e.g., CD3-redirecting technologies or CAR-T cell therapy); * Prior anti-myeloma therapies within the specified timeframes before enrollment: * Previous treatment with GPRC5D-targeted therapy; * Genetically modified adoptive cell therapy (e.g., chimeric antigen receptor T-cell \[CAR-T\], natural killer \[NK\] cell therapy) within 3 months; * Targeted therapy, investigational drugs, or invasive investigational medical devices within 21 days or 5 half-lives (whichever is longer); * Bispecific antibody therapy for multiple myeloma within 21 days or 5 half-lives (whichever is longer); * Cytotoxic therapy or monoclonal antibodies within 21 days; * Proteasome inhibitor therapy within 14 days; * Immunomodulatory drug therapy within 7 days; * Radiotherapy within 14 days (except low-dose palliative radiation \[10-30 Gy\]); * Prior intolerance to Pomalidomide (applies to treatment cohorts containing Pomalidomide); * Prior intolerance to Bortezomib (applies to treatment cohorts containing bortezomid); * Prior intolerance to Lenalidomide (applies to treatment cohorts containing Lenalidomide); * Prior intolerance to Daratumumab (applies to treatment cohorts containing Daratumumab).