Nasopharyngeal Airway Combined With Nasal High-flow Oxygen Therapy During Painless Gastroscopy in Obesity Patients

NCT06966934 · tracked via the Priya Life Science China tracker

Sponsor

Nanjing First Hospital, Nanjing Medical University

Phase

Not applicable

Started

2025-05-14

Last updated

2025-07-22

Condition(s) studied

HypoxiaObesityGastrostomy

Investigational drug(s) / intervention(s)

NPA

NPA: After sedation, the nasopharyngeal airway (NPA) is inserted when the patient's breathing becomes slightly slow but stable and the eyelash reflex disappears.

Study summary

Gastroscopy is a commonly used, direct, and reliable method for screening and diagnosing digestive tract diseases. However, as an invasive examination, it can cause adverse reactions such as pain, nausea, vomiting, and choking cough in patients. Compared with ordinary gastroscopy, painless gastroscopy offers higher comfort and satisfaction for patients and greater convenience for endoscopists during operation.

The most common complication of painless gastroscopy diagnosis and treatment is hypoxia. High-flow nasal cannulala (HFNC) provides a higher oxygen concentration and flow rate than an ordinary nasal catheter. It has the functions of heating and humidifying, which can relieve the pressure on the nasal mucosa cilia, keep the airway unobstructed and moist, and reduce the risk of epistaxis. Due to changes in airway anatomical structures such as fat accumulation in the head and neck and hyperplasia of oropharyngeal soft tissues, obese patients are more prone to hypoxia during gastroscopy under sedation. Therefore, HFNC is often used to reduce the occurrence of hypoxia.

The nasopharyngeal airway (NPA) is used to maintain the patency of the upper respiratory tract and is suitable for patients with spontaneous breathing but partial obstruction of the upper respiratory tract. It is worth exploring how effective the combination of HFNC and NPA is in improving hypoxemia in obese patients during sedation.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: 1. Patients undergoing painless gastroscopy; 2. Patients with an age greater than 18 years old; 3. American Society of Anesthesiologists (ASA) physical status classification from Grade I to Grade III; 4. Body Mass Index (BMI) greater than 28 kg/m² Exclusion Criteria: 1. Patients with contraindications to endoscopic procedures or those who refuse sedation/anesthesia; 2. Patients allergic to propofol, eggs, soybeans, milk, etc.; 3. Patients with gastrointestinal tract obstruction and gastric emptying disorders; 4. Patients with acute pharyngitis, tonsillitis, and upper respiratory tract infections; 5. Patients in the acute exacerbation stage of respiratory diseases such as asthma, bronchitis, and chronic obstructive pulmonary disease (COPD); 6. Patients with acute arrhythmia and those with severe heart diseases (congenital diseases, valvular diseases); 7. Patients with severe hepatic and renal insufficiency who require alternative treatment; 8. Patients with severe mental disorders who need medications to control their symptoms; 9. Patients with moderate or above anemia, abnormal coagulation function, and hematological diseases; 10. Patients with nasal cavity lesions leading to severe nasal congestion; 11. Pregnant and lactating patients.

Primary outcome measure(s)

incidence of hypoxia — 6 mintues after gastroscopy completion
75% ≤ SpO2 \< 90% for \<60 s

Trial sites (1)

Facility	City	Region	Status
Nanjing First Hospital	Nanjing	China	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06966934 on ClinicalTrials.gov ↗ ← All trials in China