Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent With or Without Autonomous Cortisol Secretion
complete ACTH stimulation test the day after surgery and complete ACTH stimulation test 1 or 4 week for patients with Adrenal Insufficiency
complete ACTH stimulation test the day after surgery and complete ACTH stimulation test 1 or 4 week for patients with Adrenal Insufficiency: patients complete ACTH stimulation test on the one day after surgery and complete ACTH stimulation test 1 or 4 week for patients with Adrenal Insufficiency
Study summary
To evaluate the incidence of adrenal insufficiency after surgery in Primary aldosteronism (PA) patients concurrent with or without autonomous cortisol secretion (ACS). To assess the recovery time of postoperative adrenal insufficiency in patients. And to explore the clinical characteristics and predictive indicators of patients requiring postoperative hormone replacement therapy.
Eligibility
Sex
ALL
Min age
18 Years
Max age
70 Years
Healthy volunteers
No
* A confirmed diagnosis of primary aldosteronism or autonomous cortisol secretion;
② Completion of unilateral adrenal surgery;
③ Voluntary participation and obtaining informed consent. (2) Exclusion criteria
* Patients with typical clinical manifestations of Cushing's syndrome;
* Patients suspected of having bilateral cortisol over-secretion, such as PBMAH or PPNAD; ③ Patients with severe surgical complications, unstable postoperative condition (not due to cortical insufficiency), and difficulty completing the ACTH stimulation test;
* History of ACTH allergy;
* Patients requiring long-term hormone therapy for other diseases (such as autoimmune diseases);
* Severe liver and kidney dysfunction (ALT ≥ 3 times the upper limit of normal; patients undergoing dialysis or with an estimated glomerular filtration rate \< 30 ml/min/m2); ⑦ History of contralateral adrenal surgery; ⑧ Patients with poor compliance who are unable to complete the study.
Primary outcome measure(s)
the Incidence rate of Adrenal Insufficiency After Surgery — the one day after surgery the Incidence rate of Adrenal Insufficiency After Surgery on the one day after surgery，which is defined as serum cortisol ≤ 390nmol/l 60 minutes after ACTH continuous infusion
the recovery time of postoperative Adrenal Insufficiency in patients — the one day after surgery, or 1 and 4 weeks after surgery, or 3 or 6 months after surgery the recovery time of postoperative Adrenal Insufficiency in patients. The patients will be completed ACTH stimulation test at 1 and 4 weeks after surgery. If serum cortisol \> 390nmol/l 60 minutes after ACTH continuous infusion，the patients will be considered as recovery
the clinical characteristics and predictive indicators of patients requiring postoperative hormone replacement therapy — 3 or 6 months after surgery the clinical characteristics and predictive indicators of patients requiring postoperative hormone replacement therapy
Trial sites (1)
Facility
City
Region
Status
the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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