Pathological Type，Gene Mutation and Clinical Characteristics of Unilateral Primary Aldosteronism

Condition(s) studied

Investigational drug(s) / intervention(s)

Tissue specimens were stained by histopathology of hematoxylin-eosin: Whole slide images were created by scanning the complete histologic slide to produce high-resolution digital files of the histopathology of hematoxylin-eosin and CYP11B2 immunostained sections.Tissue sections of all blocks from each resected adrenal were evaluated by hematoxylin and eosin and CYP11B2 immunostaining and adrenal specimens were categorized as classical or nonclassical histopathologic findings of unilateral PA according to the HISTALDO consensus; Genotyping was performed using CYP11B2 (aldosterone synthase)-guided sequencing

Study summary

1. Aim to investigate the pathological feature of UPA in Asians
2. To clarify the relationship between pathology, clinical phenotype, genetic mutation and surgical outcome of UPA in Asians.
3. To explore a new pathological type of unilateral primary aldosterone

Eligibility

Primary outcome measure(s)

• Define the aldosterone-producing adenoma and aldosterone-producing nodule(classical)proportions — 2 weeks after surgery
  Adrenal operative specimens were diagnosed as aldosterone-producing adenoma、aldosterone-producing nodule、aldosterone-producing micronodules、aldosterone-producing diffusehyperplasia according to HE and CYP11B2 staining
• The proportion with genetic mutations — 2 weeks after surgery
  The adrenal tumor was diagnosed by gene sequencing as KCNJ5 mutation, ATP1A1 mutation, ATP2B3 mutation or CACNA1D mutation,etc.
• Analyze the Aldosterone level and renin level Characteristics — 2 weeks after surgery
  Aldosterone level（pg/ml）, renin level（uIU/ml）, blood potassium（mmol/L） and blood pressure are the main clinical indicators of primary aldosteronism(Aldosterone level divided by renin level to obtain ARR, ARR greater than 20 consider whether aldosterone autonomic secretion),different pathological types of aldosteronomas were measured to analyze whether there were differences in clinical characteristics of adrenal tumors of different pathological types

Trial sites (1)

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