Dynamic Changes of Ductus Arteriosus in < 31 Weeks Preterm Infants: an Observational Study

Condition(s) studied

Investigational drug(s) / intervention(s)

observation group: in the group, no intervention was given, and the preterm infants were diagnosed with respiratory distress syndrome(RDS)

control group: in the group, no intervention was given, but the preterm infants were diagnosed without respiratory distress syndrome(RDS)

Study summary

The ductus arteriosus quickly closes itself. is an important channel connecting the maternal fetal circulation before birth. After birth, this ductus arteriosus generally no longer has a physical function, so ductus arteriosus quickly closes itself. The persistent presence of ductus arteriosus leads to significant pressure changes in the systemic and pulmonary circulation, which have adverse effects on extremely/very premature infants. Therefore, persistent patent ductus arteriosus (PDA) is a systemic disease.

Eligibility

Primary outcome measure(s)

• the incidence of patent ductus arteriosus(PDA) — three months after birth
  when did the ductus arteriosus close
• dynamic changes of ductus arteriosus in diameter, velocity and direction of blood flow — after admission, 12 hour, 24 hour, 48 hour, 72 hour, 96 hour, 120 hour, 144 hour, 168 hour, 192 hour, 216 hour, 240 hour and 2 weeks or any time of ductus arteriosus closed
  dynamic changes of ductus arteriosus in diameter, velocity and direction of blood flow were measured

Trial sites (1)

More Daping Hospital and the Research Institute of Surgery of the Third Military Medical University trials in China

Other trials for the same condition