This is a prospective, single-arm, multicenter, phase II clinical trial to evaluate the efficacy and safety of AZA（azacytidine）combined with the R-GemOx (rituximab, gemcitabine and oxaliplatin) regimen as first-line treatment in elderly diffuse large B-cell lymphoma (DLBCL) patients.
Eligibility
Sex
ALL
Min age
60 Years
Max age
90 Years
Healthy volunteers
No
Key Inclusion Criteria:
1. Subjects fully understand and voluntarily participate in this study and sign informed consent.
2. Aged ≥60 years, both male and female.
3. Pathologically confirmed DLBCL
4. There must be at least one measurable or evaluable lesion that meets the evaluation criteria for Lugano 2014 lymphoma.
5. No previous chemotherapy or radiotherapy for DLBCL has been received.
6. Expected survival ≥3 months.
Key Exclusion Criteria:
1. DLBCL combined with other types of lymphoma. Transformed DLBCL.
2. DLBCL with central nervous system invasion.
3. The patients have contraindications to any drug in the combined treatment.
4. Patients with the infection of human immunodeficiency virus (HIV) and/or acquired immunodeficiency syndrome.
5. Mentally ill persons or persons unable to obtain informed consent.
6. The investigators think that the patient is not suitable for the study.
Primary outcome measure(s)
Objective response rate(ORR) — Up to 8 cycles (each cycle is 21 days) To investigate the preliminary anti-tumor efficacy
Trial sites (1)
Facility
City
Region
Status
Daping Hospital, Third Military Medical University (Army Medical University)
Chongqing
China
More Daping Hospital and the Research Institute of Surgery of the Third Military Medical University trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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