Comparison of Ciprofol and Propofol Under IoC1 and IoC2 Monitoring for Adenotonsillectomy

Condition(s) studied

Investigational drug(s) / intervention(s)

Ciprofol group: In the Ciprofol group,children were given Ciprofol 0.6-0.8 mg/kg during anesthesia induction,and ciprofol 1.2-2 mg·kg-¹·h-¹for anesthesia maintenance.Throughout the entire process, we continuously monitor vital signs and IoC1/IoC2.

Propofol group: In the Propofol group,children were given Propofol 2.5-3.5 mg/kg during anesthesia induction,and propofol 6-10 mg·kg-¹·h-¹for anesthesia maintenance.Throughout the entire process, we continuously monitor vital signs and IoC1/IoC2.

Study summary

The goal of this clinical trial is to compare the Ciprofol and Propofol Under IoC1 and IoC2 Monitoring for Adenotonsillectomy Participants will be randomly allocated to two groups: Ciprofol group (Group C) and Propofol group (Group P). For those in Group C: they will be given ciprofol during anesthesia induction and maintenance .For those in Group P: they will be pgiven ciprofol during anesthesia induction and maintenanc This study evaluates ciprofol versus propofol under IoC1/IoC2 guidance in pediatric T\&A, providing evidence for ciprofol's efficacy and safety in pediatric anesthesia.

Eligibility

Primary outcome measure(s)

• Induction Compliance checklist(ICC) — during the time of anesthesia induction ,1 minute-10 minutes
  Induction Compliance checklist(ICC) will be recorded during the time of anesthesia induction.defined as a score out of 10.A score of 0 indicates perfect cooperation
• The time to loss of consciousness during anesthesia induction — after the injection of anesthetic ,1second-5miutes
  The time to loss of consciousness during anesthesia induction will be recorded after the injection of anesthetic
• sedation/consciousness (IoC1) — intraoperative period,10 minutes-1 hours
  sedation/consciousness (IoC1) will be recorded at 2 time points,including the time of intubation(T2) and mouth gag placement(T3)
• analgesia/pain-stress (IoC2) — intraoperative period,10 minutes-1 hours
  analgesia/pain-stress (IoC2) will be recorded at 2 time points,including the time of intubation(T2) and mouth gag placement(T3)

Trial sites (1)

More Maternal and Child Health Hospital of Hubei Province trials in China

Other trials for the same condition