Disorders of ConsciousnessSevere Brain InjuryUnresponsive Wakefulness SyndromeMinimally Conscious State
Investigational drug(s) / intervention(s)
tTIS
tTIS: CM-pf tTIS
Study summary
The purpose of this academic lead study is to explore the effect of noninvasive neuromodulation of the CM-pf via tTIS for patients with disorders of consciousness.
Eligibility
Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria:
* traumatic and nontraumatic etiology of VS/UWS or MCS according to published diagnostic criteria.
Exclusion Criteria:
* patients in coma, with less than 1 week after acute brain insult, with fluctuating diagnosis on baseline assessment, and with a metallic cerebral implant or pacemaker, and with epilepsy.
Primary outcome measure(s)
CRS-R total score changes — From enrollment to the end of treatment at 10 days Coma Recovery Scale-Revised scale score, with score ranging from 0 to 23, was used to evaluate the consciousness condition.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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