Sufentanil injection: Different concentrations of sufentanil were administered to three different subgroups of patients in the same way
Placebo: Placebo
Study summary
1. To analyze the association of different doses of opioids on myocardial injury/protection through BMP-6/SMAD pathway.
2. To observe the effect of different doses of opioids on the expression of BMP-6 in bone marrow.
3. To investigate the relationship between different doses of opioids and BMP-6 and perioperative cardiovascular adverse events in patients with lower extremity fracture surgery.
Eligibility
Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* There were 160 patients aged 18-65 years and older who needed surgery for lower extremity fracture.
* ASA grades I to III, gender is not limited.
Exclusion Criteria:
* Patients with acute myocardial infarction in the last 6 months, those with a history of heart failure, and those with elevated troponin levels before injury.
* Old fracture
* Stroke patients
* Liver cirrhosis, kidney failure
* Serious systemic infections, alcoholism, drug dependence
* Pathological fracture
* Use of glucocorticoids in the past one month
* Diabetic
Primary outcome measure(s)
Serum BMP6 — Immediate postoperative measurement Dose measurement of BMP6 in serum
Trial sites (1)
Facility
City
Region
Status
Second Hospital of Shanxi Medical University
Taiyuan
Shanxi
More Second Hospital of Shanxi Medical University trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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