Remote Ischemic Conditioning for Efficacy in Patients With Aneurysmal Subarachnoid Hemorrhage

NCT06711302 · tracked via the Priya Life Science China tracker

Sponsor

Beijing Tiantan Hospital

Phase

Not applicable

Started

2025-07-01

Last updated

2025-07-10

Condition(s) studied

Subarachnoid HemorrhageCerebrovascular DisordersBrain DiseasesStrokeCardiovascular DiseasesVascular DiseasesNervous System Diseases

Investigational drug(s) / intervention(s)

Sham RICRemote Ischemic Conditioning treatment instrument

Sham RIC: Remote Ischemic Conditioning is given twice a day with 60mmHg pressure.

Remote Ischemic Conditioning treatment instrument: Remote Ischemic Conditioning is given twice a day with 200mmHg pressure.

Study summary

Several recent large-scale clinical trials aimed at improving subarachnoid hemorrhage(SAH) outcomes have concluded with negative results, failing to enhance the prognosis for these patients. Consequently, there is an urgent demand for novel treatment strategies and approaches to address the challenges posed by SAH.

Remote ischemic conditioning(RIC) has gained considerable attention in the treatment of stroke, particularly ischemic stroke, with numerous studies demonstrating its potential to enhance neurological outcomes compared to conventional treatments alone.RIC for the treatment of SAH is an investigative strategy in its initial stages. The neuroprotective effects of RIC, particularly its potential to preserve cranial nerve function and ameliorate neurological deficits, confer significant value in the treatment of SAH patients.

The precise manner in which SAH patients may benefit from RIC treatment, and the mechanisms by which it improves neurological function, remain to be fully understood. Consequently, randomized controlled trials are necessary to validate the efficacy of RIC in this patient population and to delineate the optimal therapeutic protocols for its application.

Based on the above discussion, this study aims to explore the efficacy and safety of RIC in the treatment of SAH.

Eligibility

Sex

ALL

Min age

18 Years

Max age

80 Years

Healthy volunteers

Inclusion Criteria: 1. Patients with aneurysmal subarachnoid hemorrhage confirmed by imaging examination (diagnosed by computed tomography and confirmation of an intracranial aneurysm by CT angiography or digital subtraction angiography); 2. The Hunt-Hess grade is 2-3 at admission; 3. Onset of aneurysmal subarachnoid hemorrhage ≤72 hours; 4. The responsible aneurysm has been treated by endovascular interventional therapy; 5. 18≤ age ≤80 years old; 6. Informed consent must be obtained from participants or legally authorized representatives. Exclusion Criteria: 1. Patients with other intracerebral hemorrhage or other types of subarachnoid hemorrhage; 2. Previous neurological deficits (mRS Score ≥1) or psychiatric disorders that can confound neurological or functional assessments; 3. With severe comorbidities and a life expectancy of less than 90 days; 4. Refractory hypertension (Systolic blood pressure\> 180 mmHg or diastolic blood pressure \>110 mmHg); 5. Contraindications of RIC: severe soft tissue injury of the lower limbs, etc; 6. Concurrent participation in another protocol investigating a different experimental therapy; 7. Any condition that the investigator believes may increase the patient's risk.

Primary outcome measure(s)

Proportion of mRS (0-2) — 90±7 days
Modified Rankin Scale, mRS; min:0, max:6; A smaller score indicates a better prognosis.

Trial sites (1)

Facility	City	Region	Status
Beijing Tiantan Hospital	Beijing	China

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06711302 on ClinicalTrials.gov ↗ ← All trials in China