Dual-site Cross-frequency Coupled Transcranial Electrical Stimulation Modulates Working Memory of Patients With Post-stroke Cognitive Impairment

Condition(s) studied

Investigational drug(s) / intervention(s)

occupational therapy: occupational therapy (especially cognitive therapy) 40min a day for 5 days

real tACS: real theta-gamma CFC tACS for 40min a day for 5 days during cognitive therapy

sham tACS: sham theta-gamma CFC tACS for 40min a day for 5 days during cognitive therapy

Study summary

This clinical trial aims to explore the effect of dual-site theta-gamma cross-frequency coupled transcranial alternating current stimulation in the frontal and parietal region on the working memory ability of patients with cognitive impairment after stroke, and to evaluate the safety of this protocol. The main purpose is to answer the following question: Can dual-site cross-frequency coupled tACS in the frontal parietal region improve the performance of working memory and cognitive-motor dual tasks in stroke patients? What is its mechanism of action? Researchers will compare the effects of real cross-frequency coupled stimuli and sham stimuli to see if the real stimuli can bring better results to patients. Participants will receive 40 minutes of real or sham electrical stimulation once a day for 5 consecutive days. Clinical evaluations (cognitive scales) and fNIRS were conducted respectively before and after stimulation to record the relevant brain activities at rest and during cognitive tasks

Eligibility

Primary outcome measure(s)

• n-back task accuracy rate — Baseline and 5-days
  n-back task record accuracy rate
• n-back task reaction time — Baseline and 5-days
  n-back task record reaction time
• function connectivity during n-back task — Baseline and 5-days
  n-back task with fNIRS to record Oxy-Hb Concentration
• Verbal fluency test（VFT）accuracy rate — Baseline and 5-days
  VFT task record accuracy rate
• Verbal fluency test（VFT）reaction time — Baseline and 5-days
  VFT task record reaction time
• function connectivity during Verbal fluency test（VFT） — Baseline and 5-days
  VFT task with fNIRS to record Oxy-Hb Concentration

Trial sites (1)

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