Liberal or Adhere to Recommendations for PCC Management in Major Bleeding Following Trauma

Inclusion Criteria: 1. Age ≥18 years old or \< 80 years old 2. Trauma treated in resuscitation unit/emergency room patient 3. Hospital admission within 24h after injury 4. Assessment of blood consumption (ABC) score ≥2 points. Exclusion Criteria: 1. PCC was used before admission 2. Anticoagulant drugs (such as low molecular weight heparin, rivaroxaban, warfarin, etc.) 3. Previous venous thrombosis (VTE, Patients with a history of coronary artery stents within 3 months of pulmonary embolism and myocardial infarction) 4. Patients with traumatic cardiac arrest in hospital 5. Women during breastfeeding, pregnancy or pregnancy 6. Patients with hemophilia A and other blood system diseases, severe liver disease, cirrhosis and other coagulation dysfunction